ArticleCell reports2016
Self-Antigen-Driven Thymic B Cell Class Switching Promotes T Cell Central Tolerance.
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Article in Cell reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 55 citations in OpenAlex.
- Immune reset: what do we learn from bone marrow transplantation.Medical review (2021) · 2026Review
- Reversing pregnancy-induced B cell sensitization to facilitate the induction of transplant tolerance in postpartum recipients.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2026Article
- Unbiased recording and identification of thymic cellular interactomes using synthetic Notch receptors.Nature communications · 2026Article
- AIRE transcriptional condensates in central tolerance: a multiscale mechanistic perspective.Frontiers in immunology · 2026Review
- Sterile production of interferons in the thymus.Journal of immunology (Baltimore, Md. : 1950) · 2025Review
- Self-Antigens Select B Cells: A New Perspective on B Cell Selection and Function.European journal of immunology · 2025Review
- Thymflammation: The Role of a Constitutively Active Inflammatory Network and "Ectopic" Cell Types in the Thymus in the Induction of T Cell Tolerance and Beyond.Immunological reviews · 2025Review
- Thymic Interferons: A Little Goes a Long Way.Immunological reviews · 2025Review
- Antigen presentation for central tolerance induction.Nature reviews. Immunology · 2025Review
- Early-life homeostatic differentiation of thymus-resident B cells into memory B cells.Frontiers in immunology · 2025Article
- Thymic B cells in aging and autoimmune disease.Frontiers in immunology · 2025Review
- Direct presentation of inflammation-associated self-antigens by thymic innate-like T cells induces elimination of autoreactive CD8Nature immunology · 2024Article
- Sterile production of interferons in the thymus affects T cell repertoire selection.Science immunology · 2024Article
- Article
- EvaluatingFrontiers in immunology · 2024Review
- Autoimmunity in thymic epithelial tumors: a not yet clarified pathologic paradigm associated with several unmet clinical needs.Frontiers in immunology · 2024Review
- Intragraft B cell differentiation during the development of tolerance to kidney allografts is associated with a regulatory B cell signature revealed by single cell transcriptomics.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2023Article
- CCR4 and CCR7 differentially regulate thymocyte localization with distinct outcomes for central tolerance.eLife · 2023Article
- Thymus antibody-secreting cells possess an interferon gene signature and are preferentially expanded in young female mice.iScience · 2023Article
- Type III interferon drives thymic B cell activation and regulatory T cell generation.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 2 countries.
Jason PereraCommittee on Immunology, University of Chicago, Chicago, IL 60637, USA; Department of Medicine, Section of Rheumatology, and Knapp Center for Lupus and Immunology Research, University of Chicago, Chicago, IL 60637, USA.
Zhong ZhengDepartment of Medicine, Section of Rheumatology, and Knapp Center for Lupus and Immunology Research, University of Chicago, Chicago, IL 60637, USA.
Shuyin LiDepartment of Medicine, Section of Rheumatology, and Knapp Center for Lupus and Immunology Research, University of Chicago, Chicago, IL 60637, USA.
Herman GudjonsonCommittee on Immunology, University of Chicago, Chicago, IL 60637, USA; Graduate Program in the Biophysical Sciences, Department of Chemistry, University of Chicago, Chicago, IL 60637, USA.
Olga KalininaKnapp Center for Lupus and Immunology Research, Department of Pathology, University of Chicago, Chicago, IL 60637, USA.
Jennifer I C BenichouThe Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat Gan 52900, Israel.
Katharine E BlockCommittee on Immunology, University of Chicago, Chicago, IL 60637, USA; Department of Medicine, Section of Rheumatology, and Knapp Center for Lupus and Immunology Research, University of Chicago, Chicago, IL 60637, USA.
Yoram LouzounDepartment of Mathematics and Gonda Brain Research Center, Bar-Ilan University, Ramat Gan 52900, Israel.
Dengping YinSection of Transplantation, Department of Surgery, University of Chicago, Chicago, IL 60637, USA.
Anita S ChongSection of Transplantation, Department of Surgery, University of Chicago, Chicago, IL 60637, USA.
Aaron R DinnerCommittee on Immunology, University of Chicago, Chicago, IL 60637, USA; Graduate Program in the Biophysical Sciences, Department of Chemistry, University of Chicago, Chicago, IL 60637, USA.
Martin WeigertCommittee on Immunology, University of Chicago, Chicago, IL 60637, USA; Knapp Center for Lupus and Immunology Research, Department of Pathology, University of Chicago, Chicago, IL 60637, USA.
Haochu HuangCommittee on Immunology, University of Chicago, Chicago, IL 60637, USA; Department of Medicine, Section of Rheumatology, and Knapp Center for Lupus and Immunology Research, University of Chicago, Chicago, IL 60637, USA. Electronic address: hhuang@bsd.uchicago.edu.
University of Chicago · USBar-Ilan University · IL
Funding
INTERDISCIPLINARY TRAINING PROGRAM IN IMMUNOLOGYT32AI007090 · NIAID · UNIVERSITY OF CHICAGO · PI Peter Aidan Savage · 1985 to 2026
$11.7MGraduate Program in Biophysical Sciences at the University of Chicago - Renewal 0T32EB009412 · NIBIB · UNIVERSITY OF CHICAGO · PI ENGEL, GREGORY S, SOSNICK, TOBIN R · 2009 to 2023
$4.9MThymic B cells and T cell selectionR01AI087645 · NIAID · UNIVERSITY OF CHICAGO · PI HUANG, HAOCHU · 2011 to 2015
$2.0MNIAID NIH HHS R01 AI087645NIAID NIH HHS T32 AI007090NIBIB NIH HHS T32 EB009412
Abstract
B cells are unique antigen-presenting cells because their antigen presentation machinery is closely tied to the B cell receptor. Autoreactive thymic B cells can efficiently present cognate self-antigens to mediate CD4
Indexed as
AnimalsAntigen-Presenting CellsAutoantigensB-LymphocytesCD4-Positive T-LymphocytesCentral ToleranceHumansImmunoglobulin Class SwitchingLymphocyte ActivationMiceThymocytesT-LymphocytesAutoantigensantigen presentationautoreactive B cellautoreactive T cellB cell class switchingself-antigenT cell negative selectionthymic B cellstolerance
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.