ArticleBiophysical journal2016
A Tensegrity Model of Cell Reorientation on Cyclically Stretched Substrates.
Article in Biophysical journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Research on the Range of Stiffness Variation in a 2D Biomimetic Spinal Structure Based on Tensegrity Structures.Biomimetics (Basel, Switzerland) · 2025Article
- Bending-activated biotensegrity structure enables femaleScience advances · 2023Article
- A Statistical Mechanics Approach to Describe Cell Reorientation Under Stretch.Bulletin of mathematical biology · 2023Article
- The influence of nanotopography on cell behaviour through interactions with the extracellular matrix - A review.Bioactive materials · 2022Review
- Chronic lung diseases: entangled in extracellular matrix.European respiratory review : an official journal of the European Respiratory Society · 2022Review
- Mechanobiology in wound healing.Biophysical journal · 2022Article
- A Fully Integrated Arduino-Based System for the Application of Stretching Stimuli to Living Cells and Their Time-Lapse Observation: A Do-It-Yourself Biology Approach.Annals of biomedical engineering · 2021Article
- Proximity-induced electrodeformation and membrane capacitance coupling between cells.European biophysics journal : EBJ · 2021Article
- The effect of fluid shear stress on fibroblasts and stem cells on plane and groove topographies.Cell adhesion & migration · 2020Article
- Mechanical Model for Catch-Bond-Mediated Cell Adhesion in Shear Flow.International journal of molecular sciences · 2020Article
- A NanoFE simulation-based surrogate machine learning model to predict mechanical functionality of protein networks from live confocal imaging.Computational and structural biotechnology journal · 2020Article
- Elliptical adhesive contact under biaxial stretching.Proceedings. Mathematical, physical, and engineering sciences · 2020Article
- Engineering Biomaterials and Approaches for Mechanical Stretching of Cells in Three Dimensions.Frontiers in bioengineering and biotechnology · 2020Review
- Effect of Cyclic Stretch on Neuron Reorientation and Axon Outgrowth.Frontiers in bioengineering and biotechnology · 2020Article
- Enumeration-screening method for the design of simple polygonal tensegrities.Proceedings. Mathematical, physical, and engineering sciences · 2019Article
- Universal Kinetics of the Onset of Cell Spreading on Substrates of Different Stiffness.Biophysical journal · 2019Article
- Mechanical characterization of disordered and anisotropic cellular monolayers.Physical review. E · 2018Article
- Control of cellular adhesion and myofibroblastic character with sub-micrometer magnetoelastic vibrations.Journal of biomechanics · 2018Article
- Orientations of Cells on Compliant Substrates under Biaxial Stretches: A Theoretical Study.Biophysical journal · 2018Article
- Cellular mechanosensing of the biophysical microenvironment: A review of mathematical models of biophysical regulation of cell responses.Physics of life reviews · 2017Review
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Authors and funding
4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Deciphering the mechanisms underlying the high sensitivity of cells to mechanical microenvironments is crucial for understanding many physiological and pathological processes, e.g., stem cell differentiation and cancer cell metastasis. Here, a cytoskeletal tensegrity model is proposed to study the reorientation of polarized cells on a substrate under biaxial cyclic deformation. The model consists of four bars, representing the longitudinal stress fibers and lateral actin network, and eight strings, denoting the microfilaments. It is found that the lateral bars in the tensegrity, which have been neglected in most of the existing models, can play a vital role in regulating the cellular orientation. The steady orientation of cells can be quantitatively determined by the geometric dimensions and elastic properties of the tensegrity elements, as well as the frequency and biaxial ratio of the cyclic stretches. It is shown that this tensegrity model can reproduce all available experimental observations. For example, the dynamics of cell reorientation is captured by an exponential scaling law with a characteristic time that is independent of the loading frequency at high frequencies and scales inversely with the square of the strain amplitude. This study suggests that tensegrity type models may be further developed to understand cellular responses to mechanical microenvironments and provide guidance for engineering delicate cellular mechanosensing systems.
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