Evidence map›Paper›PMID 27704465›Full record

ArticleMolecular and cellular biochemistry2017

Lymphocyte genotoxicity and protective effect of Calyptranthes tricona (Myrtaceae) against H

Débora Mara Kich, Shanna Bitencourt, Bruna Caye, Dalana Faleiro, Celso Alves, Joana Silva, Susete Pinteus, Michelle Mergener, Fernanda Majolo, Aline Augusti Boligon and 4 more

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular and cellular biochemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 21 citations in OpenAlex.

  1. Antiulcerogenic Potential of the Ethanolic Extract ofInternational journal of molecular sciences · 2022
    Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Débora Mara KichLaboratório de Cultura de Células, Programa de Pós-graduação em Biotecnologia, Centro Universitário UNIVATES, Av. Avelino Talini 171, Lajeado, RS, 959000-000, Brazil.
Shanna BitencourtLaboratório de Cultura de Células, Programa de Pós-graduação em Biotecnologia, Centro Universitário UNIVATES, Av. Avelino Talini 171, Lajeado, RS, 959000-000, Brazil.
Bruna CayeLaboratório de Cultura de Células, Programa de Pós-graduação em Biotecnologia, Centro Universitário UNIVATES, Av. Avelino Talini 171, Lajeado, RS, 959000-000, Brazil.
Dalana FaleiroLaboratório de Cultura de Células, Programa de Pós-graduação em Biotecnologia, Centro Universitário UNIVATES, Av. Avelino Talini 171, Lajeado, RS, 959000-000, Brazil.
Celso AlvesMarine Resources Research Group (GIRM), ESTM, Polytechnic Institute of Leiria, 2520-641, Peniche, Portugal.
Joana SilvaMarine Resources Research Group (GIRM), ESTM, Polytechnic Institute of Leiria, 2520-641, Peniche, Portugal.
Susete PinteusMarine Resources Research Group (GIRM), ESTM, Polytechnic Institute of Leiria, 2520-641, Peniche, Portugal.
Michelle MergenerCentro Universitário UNIVATES, Lajeado, RS, Brazil.
Fernanda MajoloLaboratório Celular e Molecular. Faculdade de Medicina, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, RS, Brazil.
Aline Augusti BoligonDepartment of Industrial Pharmacy, Phytochemical Research Laboratory, Federal University of Santa Maria, Build 26, Room 1115, Santa Maria, RS, Brazil.
Roberto Christ Vianna SantosDepartment of Microbiology and Parasitology, Oral Microbiology Research Laboratory, Federal University of Santa Maria, Build 20, Room 4212/4214, Santa Maria, RS, Brazil.
Rui PedrosaMarine Resources Research Group (GIRM), ESTM, Polytechnic Institute of Leiria, 2520-641, Peniche, Portugal.
Claucia Fernanda Volken de SouzaLaboratório de Biotecnologia de Alimentos, Programa de Pós-graduação em Biotecnologia, Centro Universitário UNIVATESRS, Lajeado, RS, Brazil.
Márcia Inês GoettertLaboratório de Cultura de Células, Programa de Pós-graduação em Biotecnologia, Centro Universitário UNIVATES, Av. Avelino Talini 171, Lajeado, RS, 959000-000, Brazil. marcia.goettert@univates.br.
Univates · BRInstituto Politécnico de Leiria · PTUniversidade Federal de Santa Maria · BRPontifícia Universidade Católica do Rio Grande do Sul · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Calyptranthes tricona is a species (Myrtaceae) native to South Brazil. Plants belonging to this family are folkloric used for analgesia, inflammation, and infectious diseases. However, little is known about the toxic potential of C. tricona. The present study aimed to evaluate the antioxidant activity of C. tricona ethanol and hexane leaf extracts, as well as verify their effect on human lymphocytes and MCF-7 cells. The extracts were subjected to preliminary phytochemical screening, antioxidant activity using DPPH and ORAC methods. Genotoxic and mutagenic effects in cultured human lymphocytes were assessed using the comet assay and the micronucleus assay, respectively. In addition, cell viability by MTT assay and fluorometric analysis of mitochondrial potential and caspases-9 activity were performed in order to verify the possible effects of both extracts on H

Indexed as

DNA DamageCell DeathFemaleHumansHydrogen PeroxideLymphocytesMCF-7 CellsMyrtaceaeOxidative StressPlant ExtractsHydrogen PeroxidePlant ExtractsCalyptranthes triconaGenotoxicityHuman lymphocytes, MCF-7, cytoprotection

Identifiers

PMID27704465
OpenAlexW2529758444

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.