Evidence map›Paper›PMID 27704393›Full record

ReviewCurrent osteoporosis reports2016

Effects of Type 1 Diabetes on Osteoblasts, Osteocytes, and Osteoclasts.

Evangelia Kalaitzoglou, Iuliana Popescu, R Clay Bunn, John L Fowlkes, Kathryn M Thrailkill

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current osteoporosis reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 3 pooled it
8.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 3 syntheses or guidelines pooled it, 111 citations in OpenAlex.

  1. Pooled it
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  4. Article
  5. Upregulation of Parathyroid Hormone Receptor 1 (International journal of molecular sciences · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Evangelia KalaitzoglouUK Barnstable Brown Diabetes Center, University of Kentucky College of Medicine, 830 S. Limestone St., Lexington, KY, 40536, USA. evangelia.kalaitzoglou@uky.edu.
Iuliana PopescuUK Barnstable Brown Diabetes Center, University of Kentucky College of Medicine, 830 S. Limestone St., Lexington, KY, 40536, USA.
R Clay BunnUK Barnstable Brown Diabetes Center, University of Kentucky College of Medicine, 830 S. Limestone St., Lexington, KY, 40536, USA.
John L FowlkesUK Barnstable Brown Diabetes Center, University of Kentucky College of Medicine, 830 S. Limestone St., Lexington, KY, 40536, USA.
Kathryn M ThrailkillUK Barnstable Brown Diabetes Center, University of Kentucky College of Medicine, 830 S. Limestone St., Lexington, KY, 40536, USA.
University of Kentucky · US

Funding

THE PHYSIOLOGY OF IGFBP DEGRADING PROTEINASES IN BONER01DK055653 · NIDDK · UNIVERSITY OF KENTUCKY · PI FOWLKES, JOHN L · 1999 to 2009
$2.0M
The Insulin/IGF-I Axis in Diabetic OsteopathyR01DK084045 · NIDDK · UNIVERSITY OF KENTUCKY · PI FOWLKES, JOHN L · 2012 to 2015
$1.3M
Effects of Sodium-dependent Glucose Co-transporter 2 Inhibition on Bone.R21AR070620 · NIAMS · UNIVERSITY OF KENTUCKY · PI NYMAN, JEFFRY STEPHEN, THRAILKILL, KATHRYN M · 2016 to 2017
$387k
The insulin/IGF axis in diabetic osteopathyR56DK084045 · NIDDK · UNIVERSITY OF KENTUCKY · PI FOWLKES, JOHN L, NYMAN, JEFFRY STEPHEN · 2018 to 2018
$150k
NIAMS NIH HHS R21 AR070620NIDDK NIH HHS R01 DK055653NIDDK NIH HHS R01 DK084045NIDDK NIH HHS R56 DK084045
6 · The paper itself

Abstract

purpose of reviewTo describe the effects of type 1 diabetes on bone cells. RECENT

findingsType 1 diabetes (T1D) is associated with low bone mineral density, increased risk of fractures, and poor fracture healing. Its effects on the skeleton were primarily attributed to impaired bone formation, but recent data suggests that bone remodeling and resorption are also compromised. The hyperglycemic and inflammatory environment associated with T1D impacts osteoblasts, osteocytes, and osteoclasts. The mechanisms involved are complex; insulinopenia, pro-inflammatory cytokine production, and alterations in gene expression are a few of the contributing factors leading to poor osteoblast activity and survival and, therefore, poor bone formation. In addition, the observed sclerostin level increase accompanied by decreased osteocyte number and enhanced osteoclast activity in T1D results in uncoupling of bone remodeling. T1D negatively impacts osteoblasts and osteocytes, whereas its effects on osteoclasts are not well characterized, although the limited studies available indicate increased osteoclast activity, favoring bone resorption.

Indexed as

Bone RemodelingOsteoblastsOsteoclastsOsteocytesAnimalsBone Diseases, MetabolicBone ResorptionDiabetes Mellitus, Type 1Fracture HealingFractures, BoneHumansOsteogenesisOsteoporosisOsteoporotic FracturesBone cellsOsteoblastsOsteoclastsOsteocytesType 1 diabetes

Identifiers

PMID27704393
PMCPMC5106298
OpenAlexW2529777799

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.