Evidence map›Paper›PMID 27704259›Full record

ArticleLung2016

The Emulsified PFC Oxycyte

Ashraful Haque, Anke H Scultetus, Francoise Arnaud, Leonora J Dickson, Steve Chun, George McNamee, Charles R Auker, Richard M McCarron, Richard T Mahon

Abstract read
PubMed Publisher
In one paragraph

Article in Lung, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Treatment of Swine Closed Head Injury with Perfluorocarbon NVX-428.Medical sciences (Basel, Switzerland) · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Ashraful HaqueNeuroTrauma Department, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD, 20910-7500, USA. ashraful.haque.ctr@mail.mil.ORCID 0000-0001-8766-1378
Anke H ScultetusNeuroTrauma Department, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD, 20910-7500, USA.
Francoise ArnaudNeuroTrauma Department, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD, 20910-7500, USA.
Leonora J DicksonDepartment of Pathology, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, MD, 20910-7500, USA.
Steve ChunNeuroTrauma Department, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD, 20910-7500, USA.
George McNameeDepartment of Surgery, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD, 20814, USA.
Charles R AukerNeuroTrauma Department, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD, 20910-7500, USA.
Richard M McCarronNeuroTrauma Department, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD, 20910-7500, USA.
Richard T MahonUndersea Medicine Department, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD, 20910-7500, USA.
Naval Medical Research Command · USUniformed Services University of the Health Sciences · USWalter Reed Army Institute of Research · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePerfluorocarbons (PFCs) can transport 50 times more oxygen than human plasma. Their properties may be advantageous in preservation of tissue viability in oxygen-deprived states, such as in acute lung injury. We hypothesized that an intravenous dose of the PFC emulsion Oxycyte

methodsIntravenous oleic acid (OA) was used to induce lung injury in anesthetized and instrumented Yorkshire swine assigned to three experimental groups: (1) PFC post-OA received Oxycyte

resultsThe median survival times for PFC post-OA, PFC pre-OA, and control were 240, 87.5, and 240 min, respectively (p = 0.001). Mean arterial pressure and mean pulmonary arterial pressure were both higher in the PFC post-OA (p < 0.001 for both parameters). Oxygen content was significantly different between PFC post-OA and the control (p = 0.001). Histopathological grading of lung injury indicated that edema and congestion was significantly less severe in the PFC post-OA compared to control (p = 0.001).

conclusionThe intravenous PFC Oxycyte

Indexed as

Acid-Base EquilibriumAcute Lung InjuryAdministration, IntravenousAnimalsArterial PressureBlood Gas AnalysisDisease Models, AnimalFemaleFluorocarbonsLactic AcidMaleOleic AcidOxygenPulmonary Wedge PressureRespiratory Distress SyndromeSeverity of Illness IndexFluorocarbonsLactic AcidOleic AcidOxygenperfluoro(t-butylcyclohexane)Acute respiratory distress syndrome (ARDS)Oleic acid (OA)Perfluorocarbon (PFC)Resuscitation and oleic acid-induced lung injury (OALI)Tissue oxygenation

Identifiers

PMID27704259
OpenAlexW2528010093

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.