ArticlePlant cell reports2017
Activating glutamate decarboxylase activity by removing the autoinhibitory domain leads to hyper γ-aminobutyric acid (GABA) accumulation in tomato fruit.
Article in Plant cell reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 51 citations in OpenAlex.
- TaGAD2 is a potential downstream effector of Rht5 in controlling wheat plant height.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Enhanced Endogenous GABA Biosynthesis Modifies Fruit Production and GABA Accumulation in a Medium-Sized Tomato Cultivar Under Salt Stress.Plant-environment interactions (Hoboken, N.J.) · 2026Article
- Comprehensive Profiling of Free Amino Acids in Litchi (Foods (Basel, Switzerland) · 2025Article
- Gamma-Aminobutyric Acid: A Novel Biomolecule to Improve Plant Resistance and Fruit Quality.Plants (Basel, Switzerland) · 2025Review
- Transcriptomic Insights into GABA Accumulation in Tomato via CRISPR/Cas9-Based Editing ofGenes · 2025Article
- Reduced content of gamma-aminobutyric acid enhances resistance to bacterial wilt disease in tomato.Plant biotechnology journal · 2025Article
- Unlocking Opportunities and Overcoming Challenges in Genetically Engineered Biofortification.Nutrients · 2025Review
- Transforming tomatoes into GABA-rich functional foods through genome editing: A modern biotechnological approach.Functional & integrative genomics · 2025Review
- Recent developments, challenges and opportunities in genome editing for crop science from a societal perspective.Frontiers in genome editing · 2025Review
- Truncation of the calmodulin binding domain in rice glutamate decarboxylase 4 (Molecular breeding : new strategies in plant improvement · 2024Article
- Review
- Recent advances of γ-aminobutyric acid: Physiological and immunity function, enrichment, and metabolic pathway.Frontiers in nutrition · 2022Review
- Comprehensive Genome-Wide Identification and Transcript Profiling of GABA Pathway Gene Family in Apple (Genes · 2021Article
- The versatile GABA in plants.Plant signaling & behavior · 2021Review
- Phenotypic effects from the expression of a deregulated AtGAD1 transgene and GABA pathway suppression mutants in maize.PloS one · 2021Article
- Genome editing inPlant biotechnology (Tokyo, Japan) · 2020Article
- An In Vivo Targeted Deletion of the Calmodulin-Binding Domain from Rice Glutamate Decarboxylase 3 (OsGAD3) Increases γ-Aminobutyric Acid Content in Grains.Rice (New York, N.Y.) · 2020Article
- Challenges and Prospects of New Plant Breeding Techniques for GABA Improvement in Crops: Tomato as an Example.Frontiers in plant science · 2020Review
- Precision Genome Engineering for the Breeding of Tomatoes: Recent Progress and Future Perspectives.Frontiers in genome editing · 2020Review
- Multiplex exome sequencing reveals genome-wide frequency and distribution of mutations in the 'Micro-Tom' Targeting Induced Local Lesions in Genomes (TILLING) mutant library.Plant biotechnology (Tokyo, Japan) · 2019Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
key messageThe C-terminal extension region of SlGAD3 is likely involved in autoinhibition, and removing this domain increases GABA levels in tomato fruits. γ-Aminobutyric acid (GABA) is a ubiquitous non-protein amino acid with several health-promoting benefits. In many plants including tomato, GABA is synthesized via decarboxylation of glutamate in a reaction catalyzed by glutamate decarboxylase (GAD), which generally contains a C-terminal autoinhibitory domain. We previously generated transgenic tomato plants in which tomato GAD3 (SlGAD3) was expressed using the 35S promoter/NOS terminator expression cassette (35S-SlGAD3-NOS), yielding a four- to fivefold increase in GABA levels in red-ripe fruits compared to the control. In this study, to further increase GABA accumulation in tomato fruits, we expressed SlGAD3 with (SlGAD3
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.