ArticleBiomechanics and modeling in mechanobiology2017
Automatic construction of subject-specific human airway geometry including trifurcations based on a CT-segmented airway skeleton and surface.
Article in Biomechanics and modeling in mechanobiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Subject-Specific Whole-Lung CFPD Coupled with PBPK/PD to Predict Inhaled Bronchodilator Response in Asthmatic and Healthy Subjects.Journal of aerosol science · 2026Article
- Article
- Multiscale simulation of respiratory airflow using physiologically consistent geometry and boundary conditions in OpenFOAM.Computers in biology and medicine · 2025Article
- Transport and deposition of beclomethasone dipropionate drug aerosols with varying ethanol concentration in severe asthmatic subjects.International journal of pharmaceutics · 2023Article
- Morphometric analysis of airways in pre-COPD and mild COPD lungs using continuous surface representations of the bronchial lumen.Frontiers in bioengineering and biotechnology · 2023Article
- A computed tomography imaging-based subject-specific whole-lung deposition model.European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences · 2022Article
- Automatic triangulated mesh generation of pulmonary airways from segmented lung 3DCTs for computational fluid dynamics.International journal of computer assisted radiology and surgery · 2022Article
- CT-derived 3D-diaphragm motion in emphysema and IPF compared to normal subjects.Scientific reports · 2021Article
- Transport and deposition of hygroscopic particles in asthmatic subjects with and without airway narrowing.Journal of aerosol science · 2020Article
- Article
- Differences in Particle Deposition Between Members of Imaging-Based Asthma Clusters.Journal of aerosol medicine and pulmonary drug delivery · 2019Article
- Aerosol deposition predictions in computed tomography-derived skeletons from severe asthmatics: A feasibility study.Clinical biomechanics (Bristol, Avon) · 2019Article
- Airway morphology and inspiratory flow features in the early stages of Chronic Obstructive Pulmonary Disease.Clinical biomechanics (Bristol, Avon) · 2019Article
- Localization of adventitious respiratory sounds.The Journal of the Acoustical Society of America · 2018Article
- A Feasible Computational Fluid Dynamics Study for Relationships of Structural and Functional Alterations with Particle Depositions in Severe Asthmatic Lungs.Computational and mathematical methods in medicine · 2018Article
- A multiscale analytical model of bronchial airway acoustics.The Journal of the Acoustical Society of America · 2017Article
- Numerical simulations of aerosol delivery to the human lung with an idealized laryngeal model, image-based airway model, and automatic meshing algorithm.Computers & fluids · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
We propose a method to construct three-dimensional airway geometric models based on airway skeletons, or centerlines (CLs). Given a CT-segmented airway skeleton and surface, the proposed CL-based method automatically constructs subject-specific models that contain anatomical information regarding branches, include bifurcations and trifurcations, and extend from the trachea to terminal bronchioles. The resulting model can be anatomically realistic with the assistance of an image-based surface; alternatively a model with an idealized skeleton and/or branch diameters is also possible. This method systematically identifies and classifies trifurcations to successfully construct the models, which also provides the number and type of trifurcations for the analysis of the airways from an anatomical point of view. We applied this method to 16 normal and 16 severe asthmatic subjects using their computed tomography images. The average distance between the surface of the model and the image-based surface was 11 % of the average voxel size of the image. The four most frequent locations of trifurcations were the left upper division bronchus, left lower lobar bronchus, right upper lobar bronchus, and right intermediate bronchus. The proposed method automatically constructed accurate subject-specific three-dimensional airway geometric models that contain anatomical information regarding branches using airway skeleton, diameters, and image-based surface geometry. The proposed method can construct (i) geometry automatically for population-based studies, (ii) trifurcations to retain the original airway topology, (iii) geometry that can be used for automatic generation of computational fluid dynamics meshes, and (iv) geometry based only on a skeleton and diameters for idealized branches.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.