ArticleEuropean journal of clinical pharmacology2017
Adverse drug events in patients with advanced chronic conditions who have a prognosis of limited life expectancy at hospital admission.
Article in European journal of clinical pharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Quality of anticholinergic burden scales and their impact on clinical outcomes: a systematic review.European journal of clinical pharmacology · 2021Pooled it
- Using Electronic Health Records to Identify Adverse Drug Events in Ambulatory Care: A Systematic Review.Applied clinical informatics · 2019Pooled it
- Article
- Medication-Related Hospital Admission Among Patients Admitted to the Emergency Ward at the University of Gondar, North West Ethiopia: A Cross Sectional Study.Drug, healthcare and patient safety · 2024Article
- Medication Assessment in an Older Population during Acute Care Hospitalization and Its Effect on the Anticholinergic Burden: A Prospective Cohort Study.International journal of environmental research and public health · 2023Article
- Individualized Medication Review in Older People with Multimorbidity: A Comparative Analysis between Patients Living at Home and in a Nursing Home.International journal of environmental research and public health · 2022Article
- Factors associated to potentially inappropriate prescribing in older patients according to STOPP/START criteria: MoPIM multicentre cohort study.BMC geriatrics · 2022Article
- Factors Associated with the Detection of Inappropriate Prescriptions in Older People: A Prospective Cohort.International journal of environmental research and public health · 2021Observational
- Factors Associated with Medication Non-Adherence among Patients with Multimorbidity and Polypharmacy Admitted to an Intermediate Care Center.International journal of environmental research and public health · 2021Article
- Therapeutic optimization through goal-oriented prescription in nursing homes.International journal of clinical pharmacy · 2021Review
- Interdisciplinary Mobile Health Model to Improve Clinical Care After Heart Transplantation: Implementation Strategy Study.JMIR cardio · 2020Article
- Adverse Drug Events and Contributing Factors Among Hospitalized Adult Patients at Jimma Medical Center, Southwest Ethiopia: A Prospective Observational Study.Current therapeutic research, clinical and experimental · 2020Article
- Medication regimen complexity on hospital admission in patients with advanced chronic conditions in need of palliative care.European journal of hospital pharmacy : science and practice · 2019Article
- Balancing medication use in nursing home residents with life-limiting disease.European journal of clinical pharmacology · 2019Article
- Can screening tools for potentially inappropriate prescriptions in older adults prevent serious adverse drug events?European journal of clinical pharmacology · 2019Article
- Evaluation of accuracy of IHI Trigger Tool in identifying adverse drug events: a prospective observational study.British journal of clinical pharmacology · 2018Observational
- Potentially inappropriate medication in palliative care patients according to STOPP-Frail criteria.European geriatric medicine · 2018Article
- Potentially inappropriate medication at hospital admission in patients with palliative care needs.International journal of clinical pharmacy · 2017Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAdverse drug events (ADEs) lead to adverse clinical outcomes such as hospitalization. There is little information about the characteristics of ADEs in patients with advanced chronic conditions and have a prognosis of limited life expectancy. This study aimed to evaluate (i) the prevalence of ADEs at the time of admission to hospital, (ii) the causality, severity, and preventability of the ADEs, and (iii) the clinical and pharmacological characteristics associated with the ADEs.
methodsThis is a prospective cross-sectional study (county of Osona, Catalonia, Spain). We included patients who required palliative care as identified by the NECPAL CCOMS-ICO tool who were hospitalized in an acute geriatric unit (AGU). A system of alerts (trigger tool) was used together with a multidisciplinary review for the detection of the ADEs.
resultsOver the course of 10 months, 235 patients were recruited. Seventy-six ADEs affecting 24.68 % of the sample were identified, and of these, 23 (30.26 % of the ADEs; 8.51 % of the sample) were directly related to hospitalization. The multivariate logistic regression analysis identified the following risk factors: presence of extreme polypharmacy (≥10 medications) (OR = 3.02; 95 % CI = 1.48-6.19), anticholinergic burden according to the Anticholinergic Drug Scale (ADS) (OR = 2.32; 95 % CI = 1.13-4.78), and treatment complexity according to the Medication Regimen Complexity Index (MRCI) scale (OR = 2.90; 95 % CI = 1.44-5.83). The vast majority (94.45 %) of the ADEs were considered to be preventable. There were no differences in the survival of the patients.
conclusionsADEs are common, largely preventable, and implicated in the hospitalization of patients who require palliative care.
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