Evidence map›Paper›PMID 27704154›Full record

ArticleInternational urogynecology journal2017

Age-related alterations in female obturator internus muscle.

Mark S Cook, Laura Bou-Malham, Mary C Esparza, Marianna Alperin

Abstract read
In one paragraph

Article in International urogynecology journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
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  6. Article
  7. Up for the tackle? The pelvic floor and rugby. A review.European journal of sport science · 2024
    Review
  8. Bidirectional Relationships between Sarcopenia and Pelvic Floor Disorders.International journal of environmental research and public health · 2024
    Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Female pelvic floor biomechanics: bridging the gap.Current opinion in urology · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mark S CookDepartment of Integrative Biology and Physiology, University of Minnesota, Minneapolis, MN, USA.
Laura Bou-MalhamDepartment of Reproductive Medicine, Division of Urogynecology and Pelvic Surgery, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093-0863, USA.
Mary C EsparzaDepartment of Orthopaedic Surgery, University of California, San Diego, San Diego, CA, USA.
Marianna AlperinDepartment of Reproductive Medicine, Division of Urogynecology and Pelvic Surgery, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093-0863, USA. malperin@ucsd.edu.ORCID http://orcid.org/0000-0002-6004-1803

Funding

UC San Diego Womens Reproductive Health Research ProgramK12HD001259 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CYNTHIA GYAMFI-BANNERMAN · 1999 to 2026
$9.1M
Impact of Aging on Structure and Function of Pelvic Floor MusclesR03AG050951 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ALPERIN, MARIANNA · 2016 to 2017
$233k
Architectural Design of the Pelvic Floor Skeletal MusclesR03HD075994 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ALPERIN, MARIANNA · 2013 to 2014
$153k
NIA NIH HHS R03 AG050951NICHD NIH HHS K12 HD001259NICHD NIH HHS R03 HD075994
6 · The paper itself

Abstract

introduction and hypothesisPelvic floor muscle rehabilitation is a widely utilized, but often challenging therapy for pelvic floor disorders, which are prevalent in older women. Regimens involving the use of appendicular muscles, such as the obturator internus (OI), have been developed for strengthening of the levator ani muscle (LAM). However, changes that lead to potential dysfunction of these alternative targets in older women are not well known. We hypothesized that aging negatively impacts OI architecture, the main determinant of muscle function, and intramuscular extracellular matrix (ECM), paralleling age-related alterations in LAM.

methodsOI and LAM were procured from three groups of female cadaveric donors (five per group): younger (20 - 40 years), middle-aged (41 - 60 years), and older (≥60 years). Architectural predictors of the excursional (fiber length, L

resultsThe mean ages of the donors in the three groups were 31.2 ± 2.3 years, 47.6 ± 1.2 years, and 74.6 ± 4.2 years (P < 0.005). The groups did not differ with respect to parity or body mass index (P > 0.5). OI L

conclusionsOur findings of age-related decreases in predicted OI force production and fibrosis suggest that these alterations should be taken into consideration, when designing pelvic floor fitness programs for older women.

Indexed as

Age FactorsAdultAgedAgingAnalysis of VarianceCadaverCollagenFemaleHumansMiddle AgedMuscle, SkeletalPelvic FloorPelvic Floor DisordersCollagenAgingMuscle architectureObturator internusPelvic floor rehabilitation

Identifiers

PMID27704154
PMCPMC5450648

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.