Evidence map›Paper›PMID 27704073›Full record

ArticleThe Analyst2016

Development of a protease-resistant reporter to quantify BCR-ABL activity in intact cells.

Angela Proctor, Imola G Zigoneanu, Qunzhao Wang, Christopher E Sims, David S Lawrence, Nancy L Allbritton

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Analyst, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Angela Proctor *Department of Chemistry, University of North Carolina, Chapel Hill, NC, 27599, USA.
Imola G Zigoneanu *Joint Department of Biomedical Engineering, University of North Carolina, Chapel Hill, NC 27599, USA, and North Carolina State University, Raleigh, NC, 27695, USA.
Qunzhao WangDepartment of Chemistry, University of North Carolina, Chapel Hill, NC, 27599, USA.
Christopher E SimsDepartment of Chemistry, University of North Carolina, Chapel Hill, NC, 27599, USA.
David S LawrenceDepartment of Chemistry, University of North Carolina, Chapel Hill, NC, 27599, USA.
Nancy L AllbrittonDepartment of Chemistry, University of North Carolina, Chapel Hill, NC, 27599, USA.
Communities In Schools of Orange County · USUniversity of North Carolina at Chapel Hill · US

Funding

Single-Cell Measurement of Lipid Signaling in Colorectal CancerR01CA177993 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ALLBRITTON, NANCY L. · 2014 to 2018
$3.0M
Peptide Reporters for Estimation of BCR-Abl Kinase Activity in ALL Patient CellsF32CA186748 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ZIGONEANU, IMOLA G. · 2014 to 2015
$77k
NCI NIH HHS F32 CA186748NCI NIH HHS R01 CA177993
6 · The paper itself

Abstract

A peptidase-resistant ABL kinase substrate was developed by identifying protease-susceptible bonds on an ABL substrate peptide and replacing flanking amino acids with non-native amino acids. After an iterative design process, the lead, or designed, peptide X-A possesses a six-fold longer life in a cytosolic lysate than that of the starting peptide. The catalytic efficiency (k

Indexed as

AnimalsCell Line, TumorFusion Proteins, bcr-ablLeukemia, Myelogenous, Chronic, BCR-ABL PositiveMicePeptide HydrolasesPeptidesPhosphorylationProtein-Tyrosine KinasesSubstrate SpecificityFusion Proteins, bcr-ablPeptide HydrolasesPeptidesProtein-Tyrosine Kinases

Identifiers

PMID27704073
PMCPMC5111365
OpenAlexW2509804323

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.