ArticlePeerJ2016
Hypernasality associated with basal ganglia dysfunction: evidence from Parkinson's disease and Huntington's disease.
Article in PeerJ, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 53 citations in OpenAlex.
- Aerodynamic and Acoustic Characteristics of Nasal Airflow in Parkinson's Disease.Journal of speech, language, and hearing research : JSLHR · 2026Article
- Variable Speech Cueing Effects in Talkers With Parkinson's Disease.American journal of speech-language pathology · 2026Article
- Speech and language biomarkers for Parkinson's disease prediction, early diagnosis and progression.NPJ Parkinson's disease · 2025Review
- Deep learning-based classification of speech disorder in stroke and hearing impairment.PloS one · 2025Article
- In Silico Decoding of Parkinson's: Speech & Writing Analysis.Journal of clinical medicine · 2024Article
- Data Representativeness in Accessibility Datasets: A Meta-Analysis.ASSETS. Annual ACM Conference on Assistive Technologies · 2022Article
- Sharing Practices for Datasets Related to Accessibility and Aging.ASSETS. Annual ACM Conference on Assistive Technologies · 2021Article
- Robust Estimation of Hypernasality in Dysarthria with Acoustic Model Likelihood Features.IEEE/ACM transactions on audio, speech, and language processing · 2020Article
- Research-based Updates in Swallowing and Communication Dysfunction in Parkinson Disease: Implications for Evaluation and Management.Perspectives of the ASHA special interest groups · 2019Article
- OBJECTIVE MEASURES OF PLOSIVE NASALIZATION IN HYPERNASAL SPEECH.Proceedings of the ... IEEE International Conference on Acoustics, Speech, and Signal Processing. ICASSP (Conference) · 2019Article
- Speech-Language Pathology Evaluation and Management of Hyperkinetic Disorders Affecting Speech and Swallowing Function.Tremor and other hyperkinetic movements (New York, N.Y.) · 2017Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough increased nasality can originate from basal ganglia dysfunction, data regarding hypernasality in Parkinson's disease (PD) and Huntington's disease (HD) are very sparse. The aim of the current study was to analyze acoustic and perceptual correlates of velopharyngeal seal closure in 37 PD and 37 HD participants in comparison to 37 healthy control speakers.
methodsAcoustical analysis was based on sustained phonation of the vowel /i/ and perceptual analysis was based on monologue. Perceptual analysis was performed by 10 raters using The Great Ormond Street Speech Assessment '98. Acoustic parameters related to changes in a 1/3-octave band centered on 1 kHz were proposed to reflect nasality level and behavior through utterance.
resultsPerceptual analysis showed the occurrence of mild to moderate hypernasality in 65% of PD, 89% of HD and 22% of control speakers. Based on acoustic analyses, 27% of PD, 54% of HD and 19% of control speakers showed an increased occurrence of hypernasality. In addition, 78% of HD patients demonstrated a high occurrence of intermittent hypernasality. Further results indicated relationships between the acoustic parameter representing fluctuation of nasality and perceptual assessment (
conclusionsIn conclusion the acoustic assessment showed that abnormal nasality was not a common feature of PD, whereas patients with HD manifested intermittent hypernasality associated with chorea.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.