ArticleBJPsych open2016
The effect of second-generation antipsychotics on hippocampal volume in first episode of psychosis: longitudinal study.
Article in BJPsych open, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04569448 (Low-Dose Adjunctive Brexpiprazole in the Treatment of Bipolar I Depression), which is not on this map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Low-Dose Adjunctive Brexpiprazole in the Treatment of Bipolar I Depression: An Open-Label Study
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- In vivo hippocampal subfield volumes in bipolar disorder-A mega-analysis from The Enhancing Neuro Imaging Genetics through Meta-Analysis Bipolar Disorder Working Group.Human brain mapping · 2022Pooled it
- Apparent Cerebellar Volumetric Stabilization and Emergent Cortical Hyperexcitability During Long-Acting Injectable Aripiprazole Maintenance in Adolescent Bipolar Disorder.Pediatric reports · 2026Article
- A longitudinal study of hippocampal subfield volumes and hippocampal glutamate levels in antipsychotic-naïve first episode psychosis patients.Molecular psychiatry · 2025Article
- Impaired Hippocampal Circuitry and Memory Dysfunction in Schizophrenia.Nature. Mental health · 2025Article
- The impact of adult neurogenesis on affective functions: of mice and men.Molecular psychiatry · 2024Review
- Smaller anterior hippocampal subfields in the early stage of psychosis.Translational psychiatry · 2024Article
- Six Decades of Dopamine Hypothesis: Is Aryl Hydrocarbon Receptor the New D2?Reports (MDPI) · 2023Review
- Subfield-specific longitudinal changes of hippocampal volumes in patients with early-stage bipolar disorder.Bipolar disorders · 2023Article
- Hippocampal subfield and amygdala nuclei volumes in schizophrenia patients with a history of violence.European archives of psychiatry and clinical neuroscience · 2020Article
- Brain Structural Correlates of Metacognition in First-Episode Psychosis.Schizophrenia bulletin · 2020Article
- Targeting Hormones for Improving Cognition in Major Mood Disorders and Schizophrenia: Thyroid Hormones and Prolactin.Clinical drug investigation · 2020Review
- Predicting rehospitalization within 2 years of initial patient admission for a major depressive episode: a multimodal machine learning approach.Translational psychiatry · 2019Article
- Differential patterns of contextual organization of memory in first-episode psychosis.NPJ schizophrenia · 2018Article
- Bulking up the hippocampus in schizophrenia: a role for 5-HTBJPsych open · 2016Article
- Age-related cortical thickness trajectories in first episode psychosis patients presenting with early persistent negative symptoms.NPJ schizophrenia · 2016Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCurrent neuroscience literature has related treatment with aripiprazole to improved memory performance and subcellular changes in the hippocampus.
aimsTo explore the volumetric changes in hippocampal grey matter in people with a first episode of psychosis (FEP) treated with second-generation antipsychotics.
methodBaseline and 1-year follow-up magnetic resonance images were obtained. Hippocampal volumes were estimated by using FreeSurfer and MAGeT-Brain. Subgroups included: aripiprazole (
resultsAripiprazole subgroup displayed significant increases in bilateral hippocampal volume compared with all other subgroups (FreeSurfer: all
conclusionsAripiprazole is a first-line, second-generation treatment option that may provide an added benefit of pro-hippocampal growth. The biological underpinnings of these changes should be the focus of future investigations and may be key towards achieving a better clinical outcome for more individuals. DECLARATION OF INTEREST: M.L. received financial assistance/compensation for research and educational events from Janssen-Ortho, Eli Lilly, Roche and Otsuka/Lundbeck Alliance. A.K.M. received financial assistance/compensation for research and educational activities from Pfizer, Janssen-Ortho, AstraZeneca and Bristol-Myers Squibb. R.J. received consultancy honorariums from Pfizer and Janssen-Ortho. COPYRIGHT AND USAGE: © The Royal College of Psychiatrists 2016. This is an open access article distributed under the terms of the Creative Commons Non-Commercial, No Derivatives (CC BY-NC-ND) licence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.