ArticleBJPsych open2016
Patient characteristics as a moderator of post-traumatic stress disorder treatment outcome: combining symptom burden and strengths.
Article in BJPsych open, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Intrusive memories of trauma: A target for research bridging cognitive science and its clinical application.Clinical psychology review · 2019Pooled it
- Double trouble: Do symptom severity and duration interact to predicting treatment outcomes in adolescent depression?Behaviour research and therapy · 2020Trial
- PTSD Psychotherapy Outcome Predicted by Brain Activation During Emotional Reactivity and Regulation.The American journal of psychiatry · 2017Trial
- Differential effect of exposure-based therapy and cognitive therapy on post-traumatic stress disorder symptom clusters: A randomized controlled trial.Psychology and psychotherapy · 2017Trial
- Predicting treatment outcome for complex posttraumatic stress disorder using the personalized advantage index.European journal of psychotraumatology · 2025Article
- The effect of mindfulness-based cognitive therapy on PTSD and depression symptoms in trauma-exposed black adults: Pilot randomized controlled trial results.Journal of mood and anxiety disorders · 2024Article
- [Personalized psychotherapy of posttraumatic stress disorder : Overview on the selection of treatment methods and techniques using statistical procedures].Der Nervenarzt · 2023Article
- Predicting non-improvement of symptoms in daily mental healthcare practice using routinely collected patient-level data: a machine learning approach.Frontiers in psychiatry · 2023Article
- The effectiveness of trauma-focused psychotherapy for complex post-traumatic stress disorder: A retrospective study.European psychiatry : the journal of the Association of European Psychiatrists · 2022Article
- Treatment of post-traumatic stress disorder and substance use disorder in adults with a history of adverse childhood experiences: A systematic review of psychological interventions.Drug and alcohol dependence reports · 2022Review
- Personalization of Treatment for Patients with Childhood-Abuse-Related Posttraumatic Stress Disorder.Journal of clinical medicine · 2021Article
- Differential Effects of Comorbid Psychiatric Disorders on Treatment Outcome in Posttraumatic Stress Disorder from Childhood Trauma.Journal of clinical medicine · 2021Article
- A Therapeutic Game for Sexually Abused Children and Adolescents (Vil Du?!): Exploratory Mixed Methods Evaluation.JMIR serious games · 2021Article
- The promise of machine learning in predicting treatment outcomes in psychiatry.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2021Article
- A systematic review of factors associated with outcome of psychological treatments for post-traumatic stress disorder.European journal of psychotraumatology · 2020Review
- Feasibility of narrative exposure therapy in an outpatient day treatment programme for refugees: improvement in symptoms and global functioning.European journal of psychotraumatology · 2020Article
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- Statistical Analysis Plan for Stage 1 EMBARC (Establishing Moderators and Biosignatures of Antidepressant Response for Clinical Care) Study.Contemporary clinical trials communications · 2017Article
- Differential predictors of DSM-5 PTSD and ICD-11 complex PTSD among African American women.European journal of psychotraumatology · 2017Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
backgroundPost-traumatic stress disorder (PTSD) psychotherapy research has failed to identify patient characteristics that consistently predict differential outcome.
aimsTo identify patient characteristics associated with differential outcome via a statistically generated composite moderator among women with childhood abuse-related PTSD in a randomised controlled trial comparing exposure therapy, skills training and their combination.
methodSix baseline patient characteristics were combined in a composite moderator of treatment effects for PTSD symptoms across the three treatment conditions through a 6-month follow-up.
resultsThe optimal moderator was the combined burden of all symptoms and emotion regulation strength. Those with high moderator scores, reflecting high symptom load relative to emotion regulation, did least well in exposure, moderately well in skills and best in the combination.
conclusionsA clinically meaningful moderator, which combines patient symptom burden and strengths, was identified. Assessment at follow-up may provide a more accurate indicator of variability in outcome than that obtained immediately post-treatment. DECLARATION OF INTEREST: None. COPYRIGHT AND USAGE: © The Royal College of Psychiatrists 2016. This is an open access article distributed under the terms of the Creative Commons Non-Commercial, No Derivatives (CC BY-NC-ND) licence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.