ArticleBJPsych open2015
Cortical thickness and sulcal depth: insights on development and psychopathology in paediatric epilepsy.
Article in BJPsych open, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 18 citations in OpenAlex.
- Review
- Intrauterine exposure to SARS-CoV-2 infection and early newborn brain development.Cerebral cortex (New York, N.Y. : 1991) · 2024Observational
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- Altered whole-brain gray matter volume in form-deprivation myopia rats based on voxel-based morphometry: A pilot study.Frontiers in neuroscience · 2023Article
- Maternal psychological distress during the COVID-19 pandemic and structural changes of the human fetal brain.Communications medicine · 2022Article
- Association Between Socioeconomic Status and In Utero Fetal Brain Development.JAMA network open · 2021Article
- Brain morphometric abnormalities in boys with attention-deficit/hyperactivity disorder revealed by sulcal pits-based analyses.CNS neuroscience & therapeutics · 2021Article
- Regional brain development analysis through registration using anisotropic similarity, a constrained affine transformation.PloS one · 2020Article
- Article
- Non-invasive laminar inference with MEG: Comparison of methods and source inversion algorithms.NeuroImage · 2018Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe relationship between cortical thickness (CThick) and sulcal depth (SDepth) changes across brain regions during development. Epilepsy youth have CThick and SDepth abnormalities and prevalent psychiatric disorders.
aimsThis study compared the CThick-SDepth relationship in children with focal epilepsy with typically developing children (TDC) and the role played by seizure and psychopathology variables.
methodA surface-based, computational high-resolution three-dimesional (3D) magnetic resonance image analytic technique compared regional CThick-SDepth relationships in 42 participants with focal epilepsy and 46 TDC (6-16 years) imaged in a 1.5 Tesla scanner. Psychiatric interviews administered to each participant yielded psychiatric diagnoses. Parents provided seizure-related information.
resultsThe TDC group alone demonstrated a significant negative medial fronto-orbital CThick-SDepth correlation. Focal epilepsy participants with but not without psychiatric diagnoses showed significant positive pre-central and post-central CThick-SDepth associations not found in TDC. Although the history of prolonged seizures was significantly associated with the post-central CThick-SDepth correlation, it was unrelated to the presence/absence of psychiatric diagnoses.
conclusionsAbnormal CThick-SDepth pre-central and post-central associations might be a psychopathology biomarker in paediatric focal epilepsy. DECLARATION INTEREST: None. COPYRIGHT AND USAGE: © 2015 The Royal College of Psychiatrists. This is an open access article distributed under the terms of the Creative Commons Non-Commercial, No Derivatives (CC BY-NC-ND) licence.
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