ArticleBJPsych open2015
Childhood IQ and risk of bipolar disorder in adulthood: prospective birth cohort study.
Article in BJPsych open, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Intelligence, educational attainment, and brain structure in those at familial high-risk for schizophrenia or bipolar disorder.Human brain mapping · 2022Pooled it
- The Association Between Familial Risk and Brain Abnormalities Is Disease Specific: An ENIGMA-Relatives Study of Schizophrenia and Bipolar Disorder.Biological psychiatry · 2019Pooled it
- Associations Between Cognitive Functions and Subsequent Mood Disorder Prognosis in Low-Risk, High-Risk and Affected Monozygotic Twins: A Seven-Year Follow-Up Study.Acta psychiatrica Scandinavica · 2026Article
- What does psychopathology research have to gain by studying all mental disorders at the same time?Journal of psychopathology and clinical science · 2026Article
- Living With the Gift of Giftedness: An Exploratory Study on the Well-Being of Intellectually Gifted Adults.The gifted child quarterly · 2025Article
- Cognitive Abilities and Educational Attainment as Antecedents of Mental Disorders: A Total Population Study of Males.Psychological science · 2025Article
- Psychiatric Symptoms, Cognition, and Symptom Severity in Children.JAMA psychiatry · 2024Article
- Evaluating the causal relationship between educational attainment and mental health.medRxiv : the preprint server for health sciences · 2024Article
- Depression severity and verbal comprehension in children and adolescents with a major depressive episode.Frontiers in psychiatry · 2024Article
- Bidirectional genetic overlap between bipolar disorder and intelligence.BMC medicine · 2022Article
- High intelligence is not associated with a greater propensity for mental health disorders.European psychiatry : the journal of the Association of European Psychiatrists · 2022Article
- Genetics, leadership position, and well-being: An investigation with a large-scale GWAS.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Article
- The joint impact of cognitive performance in adolescence and familial cognitive aptitude on risk for major psychiatric disorders: a delineation of four potential pathways to illness.Molecular psychiatry · 2018Article
- Intellectual Functioning in Offspring of Parents with Bipolar Disorder: A Review of the Literature.Brain sciences · 2017Review
- Association of Fluid Intelligence and Psychiatric Disorders in a Population-Representative Sample of US Adolescents.JAMA psychiatry · 2017Article
- Big data for bipolar disorder.International journal of bipolar disorders · 2016Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIntellectual ability may be an endophenotypic marker for bipolar disorder.
aimsWithin a large birth cohort, we aimed to assess whether childhood IQ (including both verbal IQ (VIQ) and performance IQ (PIQ) subscales) was predictive of lifetime features of bipolar disorder assessed in young adulthood.
methodWe used data from the Avon Longitudinal Study of Parents and Children (ALSPAC), a large UK birth cohort, to test for an association between measures of childhood IQ at age 8 years and lifetime manic features assessed at age 22-23 years using the Hypomania Checklist-32 (HCL-32;
resultsThere was a positive association between IQ at age 8 years and lifetime manic features at age 22-23 years (Pearson's correlation coefficient 0.159 (95% CI 0.120-0.198),
conclusionsA higher childhood IQ score, and high VIQ in particular, may represent a marker of risk for the later development of bipolar disorder. This finding has implications for understanding of how liability to bipolar disorder may have been selected through generations. It will also inform future genetic studies at the interface of intelligence, creativity and bipolar disorder and is relevant to the developmental trajectory of bipolar disorder. It may also improve approaches to earlier detection and treatment of bipolar disorder in adolescents and young adults. DECLARATION OF INTEREST: None. COPYRIGHT AND USAGE: © The Royal College of Psychiatrists 2015. This is an open access article distributed under the terms of the Creative Commons Non-Commercial, No Derivatives (CC BY-NC-ND) licence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.