Evidence map›Paper›PMID 27703550›Full record

ArticleOpen access Macedonian journal of medical sciences2016

Serum Interleukin-18 and Its Gene Haplotypes Profile as Predictors in Patients with Diabetic Nephropathy.

Ahmed I Abd Elneam, Nahla M Mansour, Nayel A Zaki, Mohamed A Taher

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Open access Macedonian journal of medical sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 12 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Ahmed I Abd ElneamMolecular Genetics and Enzymology Dept., Human Genetics Division, National Research Centre, 33 El Bohouth St. (former El Tahrir St.), Dokki 12622, Cairo, Egypt (Affiliation ID 60014618).
Nahla M MansourGut Microbiology and Immunology Group, Chemistry of Natural and Microbial Products Department, Pharmaceutical Industries Research Division, National Research Centre, 33 El Bohouth St. (former El Tahrir St.), Dokki 12622, Cairo, Egypt.
Nayel A ZakiInternal Medicine Department, Faculty of Medicine, Sohag University, Sohag, Egypt.
Mohamed A TaherMedical Biochemistry Department, Sohag Faculty of Medicine, Sohag University, Egypt.
National Research Centre · EGSohag University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDiabetic nephropathy (DN) is known as an acute microvascular complexity as a subsequence progression in diabetes mellitus type 1 and 2. Many evidence pointed that the proinflammatory cytokine Interleukin (IL)-18 might be involved in the pathogenesis of DN.

aimThe current study aimed to evaluate the association of serum IL-18 and its promoter gene polymorphisms with diabetic nephropathy.

methodsThis study included 62 diabetic nephropathy patients (DN group) compared to 52 diabetes mellitus patients (DM group). The two groups were subjected to anthropometry assessment, molecular studies including SNP genotyping by RFLP and finally statistical analysis.

resultsThe assessment of the serum IL-18 level and the frequencies of its allele and haplotype:

conclusionThese data confirm the impact of high serum IL-18 and the haplotype of the polymorphism located in the promoter region of the

Indexed as

Diabetic NephropathyhaplotypeIL-18- polymorphismsPCRRFLP

Identifiers

PMID27703550
PMCPMC5042610
OpenAlexW2498976128

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.