Evidence map›Paper›PMID 27703523›Full record

ArticleOncology letters2016

Mean platelet volume provides beneficial diagnostic and prognostic information for patients with resectable gastric cancer.

Xiao-Ming Shen, You-You Xia, Lian Lian, Chong Zhou, Xiang-Li Li, Shu-Guang Han, Yan Zheng, Fei-Ran Gong, Min Tao, Zhong-Qi Mao and 1 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncology letters, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 3 pooled it
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 3 syntheses or guidelines pooled it, 50 citations in OpenAlex.

  1. Pooled it
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  14. Liquid biopsy approach to pancreatic cancer.World journal of gastrointestinal oncology · 2021
    Review
  15. Article
  16. Platelets as messengers of early-stage cancer.Cancer metastasis reviews · 2021
    Review
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Xiao-Ming ShenDepartment of Oncology, Suzhou Xiangcheng People's Hospital, Suzhou, Jiangsu, P.R. China.
You-You XiaDepartment of Radiation Oncology, Lianyungang First People's Hospital, Lianyungang, Jiangsu, P.R. China; The Fourth Clinical Medical College, Nanjing Medical University, Nanjing, Jiangsu, P.R. China.
Lian LianDepartment of Oncology, Suzhou Xiangcheng People's Hospital, Suzhou, Jiangsu, P.R. China; Department of Oncology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, P.R. China.
Chong ZhouDepartment of Radiation Oncology, Xuzhou Central Hospital, Xuzhou, Jiangsu, P.R. China.
Xiang-Li LiDepartment of General Surgery, Suzhou Xiangcheng People's Hospital, Suzhou, Jiangsu, P.R. China.
Shu-Guang HanDepartment of General Surgery, Suzhou Xiangcheng People's Hospital, Suzhou, Jiangsu, P.R. China.
Yan ZhengDepartment of Oncology, Suzhou Xiangcheng People's Hospital, Suzhou, Jiangsu, P.R. China.
Fei-Ran GongDepartment of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, P.R. China.
Min TaoDepartment of Oncology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, P.R. China; Jiangsu Institute of Clinical Immunology, Soochow University, Suzhou, Jiangsu, P.R. China; Institute of Medical Biotechnology, Soochow University, Suzhou, Jiangsu, P.R. China; PREMED Key Laboratory for Precision Medicine, Soochow University, Suzhou, Jiangsu, P.R. China.
Zhong-Qi MaoDepartment of Minimally Invasive Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, P.R. China.
Wei LiDepartment of Oncology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, P.R. China; Jiangsu Institute of Clinical Immunology, Soochow University, Suzhou, Jiangsu, P.R. China; PREMED Key Laboratory for Precision Medicine, Soochow University, Suzhou, Jiangsu, P.R. China.
Soochow University · CNThe First People’s Hospital of Lianyungang · CNXuzhou Central Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gastric cancer is the fourth most frequent cancer and the second cause of cancer-related mortalities worldwide. Platelets play an important and multifaceted role in cancer progression. Elevated mean platelet volume (MPV) detected in peripheral blood has been identified in various types of cancer. In the present study, we investigated the application value of MPV in early diagnostic and prognostic prediction in patients with resectable gastric cancer. In total, 168 patients with resectable gastric cancer were included and separated into the gastric cancer and healthy control groups according to median pre-operatic MPV value (MPV low, <10.51 or MPV high, ≥10.51). The results showed that the pre-operatic MPV level was significantly higher in gastric cancer patients compared with the healthy subjects. Low pre-operatic MPV level correlated with improved clinicopathological features, including decreased depth of invasion, less lymphonodus metastasis and early tumor stage. The Kaplan-Meier plots showed that the patients with higher pre-operatic MPV had decreased overall survival (OS) and disease-free survival (DFS). Surgical tumor resection resulted in a significant decrease in the MPV level. The patients whose MPV level decreased following surgery had an improved OS. Multivariate Cox regression analysis revealed that the depth of invasion, lymphonodus metastasis, American Joint Committee on Cancer (AJCC) stage, and changes in MPV following surgery were prognostic factors affecting OS, and the AJCC stage and pre-operatic MPV were prognostic factors affecting DFS. In conclusion, MPV measurement can provide important diagnostic and prognostic results in patients with resectable gastric cancer.

Indexed as

diagnosisgastric cancermean platelet volumeprognosis

Identifiers

PMID27703523
PMCPMC5038875
OpenAlexW2492524003

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.