Evidence map›Paper›PMID 27703263›Full record

ArticleScientific reports2016

Unambiguous observation of blocked states reveals altered, blocker-induced, cardiac ryanodine receptor gating.

Saptarshi Mukherjee, N Lowri Thomas, Alan J Williams

Abstract read
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Saptarshi MukherjeeWales Heart Research Institute, Cardiff University School of Medicine, Heath Park, Cardiff, CF14 4XN, United Kingdom.
N Lowri ThomasWales Heart Research Institute, Cardiff University School of Medicine, Heath Park, Cardiff, CF14 4XN, United Kingdom.
Alan J WilliamsWales Heart Research Institute, Cardiff University School of Medicine, Heath Park, Cardiff, CF14 4XN, United Kingdom.

Funding

British Heart Foundation CH06/002
6 · The paper itself

Abstract

The flow of ions through membrane channels is precisely regulated by gates. The architecture and function of these elements have been studied extensively, shedding light on the mechanisms underlying gating. Recent investigations have focused on ion occupancy of the channel's selectivity filter and its ability to alter gating, with most studies involving prokaryotic K

Indexed as

AnimalsHEK293 CellsHumansIon Channel GatingIon TransportMicePotassiumRyanodine Receptor Calcium Release ChannelPotassiumryanodine receptor 2. mouseRyanodine Receptor Calcium Release Channel

Identifiers

PMID27703263
PMCPMC5050499

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.