ArticleScientific reports2016
New low-flux mixed matrix membranes that offer superior removal of protein-bound toxins from human plasma.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 72 citations in OpenAlex.
- Pooled it
- Differences in Dialysis Efficacy Have Limited Effects on Protein-Bound Uremic Toxins Plasma Levels over Time.Toxins · 2019Trial
- An In Vitro System for Studying Toxin Transport Across Hemodialysis Membranes.Artificial organs · 2026Article
- Review
- Computational modelling of hollow fibre haemodialysers: current status and future directions.Communications engineering · 2025Review
- Future of Uremic Toxin Management.Toxins · 2024Review
- Proceedings of a membrane update symposium: advancements, scientific insights, and future trends for dialysis membranes for enhanced clinical outcomes in end stage kidney disease patients.Frontiers in nephrology · 2024Article
- Pro-Arrhythmic Potential of Accumulated Uremic Toxins Is Mediated via Vulnerability of Action Potential Repolarization.International journal of molecular sciences · 2023Article
- Adsorption- and Displacement-Based Approaches for the Removal of Protein-Bound Uremic Toxins.Toxins · 2023Review
- Selectively mixed matrix hemodialysis membrane for adequate clearance ofRSC advances · 2023Article
- Research progress on the relationship between IS and kidney disease and its complications.International urology and nephrology · 2022Review
- Insights from molecular dynamics simulations of albumin adsorption on hydrophilic and hydrophobic surfaces.Journal of molecular graphics & modelling · 2022Article
- Dialysis Membranes for Acute Kidney Injury.Membranes · 2022Review
- Interaction of Human Serum Albumin with Uremic Toxins: The Need of New Strategies Aiming at Uremic Toxins Removal.Membranes · 2022Review
- Recent trends in therapeutic application of engineered blood purification materials for kidney disease.Biomaterials research · 2022Review
- Review
- A Review of Commercial Developments and Recent Laboratory Research of Dialyzers and Membranes for Hemodialysis Application.Membranes · 2021Review
- Review
- Article
- In silico comparison of protein-bound uremic toxin removal by hemodialysis, hemodiafiltration, membrane adsorption, and binding competition.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hemodialysis is a widely available and well-established treatment for patients with End Stage Renal Disease (ESRD). However, although life-sustaining, patient mortality rates are very high. Several recent studies corroborated the link between dialysis patients' outcomes and elevated levels of protein-bound uremic toxins (PBUT) that are poorly removed by conventional hemodialysis. Therefore, new treatments are needed to improve their removal. Recently, our group showed that the combination of dialysis and adsorption on one membrane, the mixed matrix membrane (MMM), can effectively remove those toxins from human plasma. However, these first MMMs were rather large in diameter and their mass transport characteristics needed improvement before application in the clinical setting. Therefore, in this study we developed a new generation of MMMs that have a smaller diameter and optimized characteristics offering superior ability in removing the PBUT indoxyl sulfate (IS) and p-cresyl sulfate (pCS) in comparison to first generation MMMs (30 and 125% respectively), as well as, a commercial dialysis membrane (more than 100% better removal).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.