ArticleNature communications2016
Analogue modulation of back-propagating action potentials enables dendritic hybrid signalling.
Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 29 citations in OpenAlex.
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- Somatic Depolarization Enhances Hippocampal CA1 Dendritic Spike Propagation and Distal Input-Driven Synaptic Plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- A Synaptic Pruning-Based Spiking Neural Network for Hand-Written Digits Classification.Frontiers in artificial intelligence · 2022Article
- Periodicity Pitch Perception Part III: Sensibility and Pachinko Volatility.Frontiers in neuroscience · 2022Article
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- Tonic GABAThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Past and Future of Analog-Digital Modulation of Synaptic Transmission.Frontiers in cellular neuroscience · 2019Review
- Neuromodulation of Axon Terminals.Cerebral cortex (New York, N.Y. : 1991) · 2018Article
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- Long-term potentiation expands information content of hippocampal dentate gyrus synapses.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
We report that back-propagating action potentials (bAPs) are not simply digital feedback signals in dendrites but also carry analogue information about the overall state of neurons. Analogue information about the somatic membrane potential within a physiological range (from -78 to -64 mV) is retained by bAPs of dentate gyrus granule cells as different repolarization speeds in proximal dendrites and as different peak amplitudes in distal regions. These location-dependent waveform changes are reflected by local calcium influx, leading to proximal enhancement and distal attenuation during somatic hyperpolarization. The functional link between these retention and readout mechanisms of the analogue content of bAPs critically depends on high-voltage-activated, inactivating calcium channels. The hybrid bAP and calcium mechanisms report the phase of physiological somatic voltage fluctuations and modulate long-term synaptic plasticity in distal dendrites. Thus, bAPs are hybrid signals that relay somatic analogue information, which is detected by the dendrites in a location-dependent manner.
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