ArticlePlant physiology2016
OsHAC1;1 and OsHAC1;2 Function as Arsenate Reductases and Regulate Arsenic Accumulation.
Article in Plant physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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Who cites it
56 citing papers in PubMed, 234 citations in OpenAlex.
- Histone variant H2A.X represses deposition of active H3K4me3 marks and restricts H2A.W incorporation.Nucleic acids research · 2026Article
- Harnessing polyploidy and nitric oxide for improved arsenic tolerance in Oryza sativa.BMC plant biology · 2025Article
- Dose-response impact of arsenite on wheat (Physiology and molecular biology of plants : an international journal of functional plant biology · 2025Article
- A transcription factor ensemble orchestrates bundle sheath expression in rice.Nature communications · 2025Article
- Geochemical Speciation, Uptake, and Transportation Mechanisms of Arsenic, Cadmium, and Lead in Soil-Rice Systems: Additional Aspects and Challenges.Antioxidants (Basel, Switzerland) · 2025Review
- Multi-Experiment and Multi-Locus Genome-Wide Association Mapping for Grain Arsenic in Rice Population.Plant direct · 2025Article
- Recent Advances in Transcriptome Analysis Within the Realm of Low Arsenic Rice Breeding.Plants (Basel, Switzerland) · 2025Review
- Control strategies for rice "straighthead" through physicochemical and biological methods on arsenic transformation and transportation.Frontiers in plant science · 2025Review
- Arsenic-induced enhancement of diazotrophic recruitment and nitrogen fixation in Pteris vittata rhizosphere.Nature communications · 2024Article
- Overexpression of bacterial γ-glutamylcysteine synthetase increases toxic metal(loid)s tolerance and accumulation in Crambe abyssinica.Plant cell reports · 2024Article
- Article
- OsCAMTA3 Negatively Regulates Disease Resistance toInternational journal of molecular sciences · 2024Article
- Nutrient and mycoremediation of a global menace 'arsenic': exploring the prospects of phosphorus and Serendipita indica-based mitigation strategies in rice and other crops.Plant cell reports · 2024Review
- The Molecular Mechanism of the Response of Rice to Arsenic Stress and Effective Strategies to Reduce the Accumulation of Arsenic in Grain.International journal of molecular sciences · 2024Review
- Multifaceted response mechanisms of Oryza sativa L. 'KDML105' to high arsenite and arsenate stress levels.Environmental science and pollution research international · 2024Article
- Article
- Allene oxide synthase 1 contributes to limiting grain arsenic accumulation and seedling detoxification in rice.Stress biology · 2023Article
- Abiotic Stress in Rice: Visiting the Physiological Response and Its Tolerance Mechanisms.Plants (Basel, Switzerland) · 2023Review
- Review
- Regulatory Mechanisms Underlying Arsenic Uptake, Transport, and Detoxification in Rice.International journal of molecular sciences · 2023Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 2 countries.
Funding
Abstract
Rice is a major dietary source of the toxic metalloid arsenic (As). Reducing its accumulation in rice (Oryza sativa) grain is of critical importance to food safety. Rice roots take up arsenate and arsenite depending on the prevailing soil conditions. The first step of arsenate detoxification is its reduction to arsenite, but the enzyme(s) catalyzing this reaction in rice remains unknown. Here, we identify OsHAC1;1 and OsHAC1;2 as arsenate reductases in rice. OsHAC1;1 and OsHAC1;2 are able to complement an Escherichia coli mutant lacking the endogenous arsenate reductase and to reduce arsenate to arsenite. OsHAC1:1 and OsHAC1;2 are predominantly expressed in roots, with OsHAC1;1 being abundant in the epidermis, root hairs, and pericycle cells while OsHAC1;2 is abundant in the epidermis, outer layers of cortex, and endodermis cells. Expression of the two genes was induced by arsenate exposure. Knocking out OsHAC1;1 or OsHAC1;2 decreased the reduction of arsenate to arsenite in roots, reducing arsenite efflux to the external medium. Loss of arsenite efflux was also associated with increased As accumulation in shoots. Greater effects were observed in a double mutant of the two genes. In contrast, overexpression of either OsHAC1;1 or OsHAC1;2 increased arsenite efflux, reduced As accumulation, and enhanced arsenate tolerance. When grown under aerobic soil conditions, overexpression of either OsHAC1;1 or OsHAC1;2 also decreased As accumulation in rice grain, whereas grain As increased in the knockout mutants. We conclude that OsHAC1;1 and OsHAC1;2 are arsenate reductases that play an important role in restricting As accumulation in rice shoots and grain.
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