ArticleDiabetes2017
Compensatory Hyperconnectivity in Developing Brains of Young Children With Type 1 Diabetes.
Registry-linked trialOpen access · bronzeAbstract read
In one paragraph
Article in Diabetes, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03428932 (Glycemic Control and the Brain in Children With Type 1 Diabetes), which is not on this map. Cited by 20 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 11% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Glycemic Control and the Brain in Children With Type 1 Diabetes
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Cognitive skills in children and adolescents with type 1 diabetes: a scoping review and meta-analysis.BMJ open diabetes research & care · 2026Pooled it
- A Pilot randomized trial to examine effects of a hybrid closed-loop insulin delivery system on neurodevelopmental and cognitive outcomes in adolescents with type 1 diabetes.Nature communications · 2022Trial
- Executive functioning-related neural processes in emerging adults with type 1 diabetes.Brain imaging and behavior · 2026Article
- Linking intrinsic brain dysfunction to behavioral outcomes in combat-exposed males with PTSD symptoms.Frontiers in psychiatry · 2025Article
- Following changes in brain structure and function with multimodal MRI in a year-long prospective study on the development of Type 2 diabetes.Frontiers in radiology · 2025Article
- Brain functional and structural changes in diabetic children. How can intellectual development be optimized in type 1 diabetes?Therapeutic advances in chronic disease · 2024Review
- Cognitive Dysfunction in Type 2 Diabetes Is Not a One-Way Process: Evidence From a Longitudinal Brain Connectivity Study.Frontiers in endocrinology · 2022Article
- Concomitant functional impairment and reorganization in the linkage between the cerebellum and default mode network in patients with type 2 diabetes mellitus.Quantitative imaging in medicine and surgery · 2021Article
- Resting-State Functional Connectivity and Psychopathology in Klinefelter Syndrome (47, XXY).Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Using multimodal MRI to investigate alterations in brain structure and function in the BBZDR/Wor rat model of type 2 diabetes.Animal models and experimental medicine · 2020Article
- Brain Function Differences in Children With Type 1 Diabetes: A Functional MRI Study of Working Memory.Diabetes · 2020Article
- The effect of chronic neuroglycopenia on resting state networks in GLUT1 syndrome across the lifespan.Human brain mapping · 2020Article
- Abnormal Functional Connectivity Density in New-Onset Type 1 Diabetes Mellitus Children: A Resting-State Functional Magnetic Resonance Imaging Study.Frontiers in psychiatry · 2020Article
- Differential Resting State Connectivity Responses to Glycemic State in Type 1 Diabetes.The Journal of clinical endocrinology and metabolism · 2020Observational
- Executive task-based brain function in children with type 1 diabetes: An observational study.PLoS medicine · 2019Observational
- Prefronto-temporal white matter microstructural alterations 20 years after the diagnosis of type 1 diabetes mellitus.Pediatric diabetes · 2018Article
- Meeting Report: 2017 International Joint Meeting of Pediatric Endocrinology Washington DC (September 14-17, 2017) Selected Highlights.Pediatric endocrinology reviews : PER · 2018Article
- Complex systems representing effective connectivity in patients with Type One diabetes mellitus.PloS one · 2018Article
- Altered eigenvector centrality is related to local resting-state network functional connectivity in patients with longstanding type 1 diabetes mellitus.Human brain mapping · 2017Article
- Effect of verbal task complexity in a working memory paradigm in patients with type 1 diabetes. A fMRI study.PloS one · 2017Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 1 country.
Manish SaggarCenter for Interdisciplinary Brain Sciences Research, Stanford University School of Medicine, Stanford, CA saggar@stanford.edu.ORCID 0000-0002-5307-2249
Eva TsalikianDivision of Endocrinology and Diabetes, Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, IA.
Nelly MaurasPediatric Endocrinology, Nemours Children's Health System, Jacksonville, FL.
Paul MazaikaCenter for Interdisciplinary Brain Sciences Research, Stanford University School of Medicine, Stanford, CA.
Neil H WhiteDepartment of Psychiatry, Washington University School of Medicine in St. Louis, St. Louis, MO.
Stuart WeinzimerDepartment of Pediatrics, Yale University School of Medicine, New Haven, CT.
Bruce BuckinghamDivision of Endocrinology and Diabetes, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA.
Tamara HersheyDepartment of Psychiatry, Washington University School of Medicine in St. Louis, St. Louis, MO.
Allan L ReissCenter for Interdisciplinary Brain Sciences Research, Stanford University School of Medicine, Stanford, CA.
Diabetes Research in Children Network (DirecNet)
Stanford University · USWashington University in St. Louis · USNemours Children's Health System · USUniversity of Iowa · USYale University · US
Funding
Yale Diabetes Research CenterP30DK045735 · NIDDK · YALE UNIVERSITY · PI Kevan C Herold, GERALD I SHULMAN · 1993 to 2026
$44.0MType 1 diabetes and the brain in children: Metabolic interventionsR01HD078463 · NICHD · NEMOURS CHILDREN'S CLINIC · PI MAURAS, NELLY, REISS, ALLAN L · 2014 to 2018
$9.9MCoordinating Center: Glucose Sensors in Type I DiabetesU01HD041890 · NICHD · JAEB CENTER FOR HEALTH RESEARCH, INC. · PI BECK, ROY W · 2001 to 2006
$4.1MYale Study of Closed-Loop Automated Glucose Control for Hypoglycemia PreventionU10HD041906 · NICHD · YALE UNIVERSITY · PI WEINZIMER, STUART ALAN · 2001 to 2011
$3.6MPrevention of Nocturnal Hypoglycemia: Effect on Neurologic Outcome in ToddlersU10HD041908 · NICHD · STANFORD UNIVERSITY · PI BUCKINGHAM, BRUCE A · 2001 to 2011
$3.5MPrevention of Hypoglycemia and Associated Complications in Type 1 DiabetesU10HD041915 · NICHD · UNIVERSITY OF IOWA · PI TSALIKIAN, EVA · 2001 to 2011
$3.4MHypoglycemia in Children and Adolescents with T1DM: Mechanisms and PreventionU10HD041918 · NICHD · NEMOURS CHILDREN'S CLINIC · PI MAURAS, NELLY · 2001 to 2011
$3.1MDiabetes Research in Children Network (DirecNet)U10HD056526 · NICHD · WASHINGTON UNIVERSITY · PI WHITE, NEIL H. · 2007 to 2011
$1.4MQuantifying the Fluctuations of Intrinsic Brain Activity in Healthy and Patient PopulationsK99MH104605 · NIMH · STANFORD UNIVERSITY · PI SAGGAR, MANISH · 2015 to 2016
$244kNICHD NIH HHS R01 HD078463NICHD NIH HHS U01 HD041890NICHD NIH HHS U10 HD041906NICHD NIH HHS U10 HD041908NICHD NIH HHS U10 HD041915NICHD NIH HHS U10 HD041918NICHD NIH HHS U10 HD056526NIDDK NIH HHS P30 DK045735NIMH NIH HHS K99 MH104605
Abstract
Sustained dysregulation of blood glucose (hyper- or hypoglycemia) associated with type 1 diabetes (T1D) has been linked to cognitive deficits and altered brain anatomy and connectivity. However, a significant gap remains with respect to how T1D affects spontaneous at-rest connectivity in young developing brains. Here, using a large multisite study, resting-state functional MRI data were examined in young children with T1D (
Indexed as
Child DevelopmentCognitionBlood GlucoseBrainCase-Control StudiesChildChild, PreschoolDiabetes Mellitus, Type 1FemaleFunctional NeuroimagingHumansHyperglycemiaHypoglycemiaMagnetic Resonance ImagingMaleNeuropsychological TestsBlood Glucose
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What OpenQuestion holds
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Registered trials
NCT03428932ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.