ArticleJournal of biological rhythms2016
Differential Phasing between Circadian Clocks in the Brain and Peripheral Organs in Humans.
Article in Journal of biological rhythms, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Machine learning identifies a compact gene set for monitoring the circadian clock in human blood.Genome medicine · 2017Pooled it
- Bidirectional regulation between circadian feeding behavior and specialized midgut clocks inbioRxiv : the preprint server for biology · 2026Article
- Transcriptional noise sets fundamental limits to decoding circadian clock phase from single-cell RNA snapshots.iScience · 2026Article
- A novel Bayesian hierarchical model for detecting differential circadian pattern in transcriptomic applications.Briefings in bioinformatics · 2025Article
- Peripheral clocks and systemicFrontiers in endocrinology · 2025Review
- Disruption of day-to-night changes in circadian gene expression with chronic tendinopathy.The Journal of physiology · 2024Article
- Diminished circadian and ultradian rhythms of human brain activity in pathological tissue in vivo.Nature communications · 2024Article
- CIRCUST: A novel methodology for temporal order reconstruction of molecular rhythms; validation and application towards a daily rhythm gene expression atlas in humans.PLoS computational biology · 2023Article
- Experimental design and power calculation in omics circadian rhythmicity detection using the cosinor model.Statistics in medicine · 2023Article
- TimeTeller for timing health: The potential of circadian medicine to improve performance, prevent disease and optimize treatment.Frontiers in digital health · 2023Article
- Likelihood-based tests for detecting circadian rhythmicity and differential circadian patterns in transcriptomic applications.Briefings in bioinformatics · 2021Article
- Genes Relevant to Tissue Response to Cancer Therapy Display Diurnal Variation in mRNA Expression in Human Oral Mucosa.Journal of circadian rhythms · 2021Article
- Clocks, Rhythms, Sex, and Hearts: How Disrupted Circadian Rhythms, Time-of-Day, and Sex Influence Cardiovascular Health.Biomolecules · 2021Review
- Extensive tissue-specific expression variation and novel regulators underlying circadian behavior.Science advances · 2021Article
- Ten-Second Electrophysiology: Evaluation of the 3DEP Platform for high-speed, high-accuracy cell analysis.Scientific reports · 2019Article
- The importance of determining circadian parameters in pharmacological studies.British journal of pharmacology · 2019Review
- LimoRhyde: A Flexible Approach for Differential Analysis of Rhythmic Transcriptome Data.Journal of biological rhythms · 2019Article
- A database of tissue-specific rhythmically expressed human genes has potential applications in circadian medicine.Science translational medicine · 2018Article
- Timing of eating in adults across the weight spectrum: Metabolic factors and potential circadian mechanisms.Physiology & behavior · 2018Review
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Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
The daily timing of mammalian physiology is coordinated by circadian clocks throughout the body. Although measurements of clock gene expression indicate that these clocks in mice are normally in phase with each other, the situation in humans remains unclear. We used publicly available data from five studies, comprising over 1000 samples, to compare the phasing of circadian gene expression in human brain and human blood. Surprisingly, after controlling for age, clock gene expression in brain was phase-delayed by ~8.5 h relative to that of blood. We then examined clock gene expression in two additional human organs and in organs from nine other mammalian species, as well as in the suprachiasmatic nucleus (SCN). In most tissues outside the SCN, the expression of clock gene orthologs showed a phase difference of ~12 h between diurnal and nocturnal species. The exception to this pattern was human brain, whose phasing resembled that of the SCN. Our results highlight the value of a multi-tissue, multi-species meta-analysis, and have implications for our understanding of the human circadian system.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.