Evidence map›Paper›PMID 27702673›Full record

ArticleThe Journal of allergy and clinical immunology2017

Mechanism of T

Weimin Liu, Sucai Liu, Mukesh Verma, Iram Zafar, James T Good, Donald Rollins, Stephen Groshong, Magdalena M Gorska, Richard J Martin, Rafeul Alam

Abstract read
In one paragraph

Article in The Journal of allergy and clinical immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers.

0numbers the graph read from it
0cells of the map it votes in
80citing papers in PubMed
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

80 citing papers in PubMed, 143 citations in OpenAlex.

  1. Review
  2. Targeting CXCR1/2 suppresses TThe journal of allergy and clinical immunology. Global · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Association of Childhood Asthma with the Concept of Exposomics: A Short Review.Medical science monitor : international medical journal of experimental and clinical research · 2025
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Influence of serum IL-36 subfamily cytokines on clinical manifestations of asthma.The journal of allergy and clinical immunology. Global · 2025
    Article
  16. Review
  17. Article
  18. Omics approaches in asthma research: Challenges and opportunities.Chinese medical journal pulmonary and critical care medicine · 2024
    Review
  19. Tailored Biologics Selection in Severe Asthma.Tuberculosis and respiratory diseases · 2024
    Article
  20. Cytotoxic CD4Med (New York, N.Y.) · 2023
    Article

20 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Weimin LiuDepartment of Medicine, Division of Allergy & Immunology, and Division of Pulmonary and Critical Care Medicine, National Jewish Health, Denver, Colo.
Sucai LiuDepartment of Medicine, Division of Allergy & Immunology, and Division of Pulmonary and Critical Care Medicine, National Jewish Health, Denver, Colo.
Mukesh VermaDepartment of Medicine, Division of Allergy & Immunology, and Division of Pulmonary and Critical Care Medicine, National Jewish Health, Denver, Colo.
Iram ZafarDepartment of Medicine, Division of Allergy & Immunology, and Division of Pulmonary and Critical Care Medicine, National Jewish Health, Denver, Colo.
James T GoodDepartment of Medicine, Division of Allergy & Immunology, and Division of Pulmonary and Critical Care Medicine, National Jewish Health, Denver, Colo; School of Medicine, University of Colorado Denver, Denver, Colo.
Donald RollinsDepartment of Medicine, Division of Allergy & Immunology, and Division of Pulmonary and Critical Care Medicine, National Jewish Health, Denver, Colo; School of Medicine, University of Colorado Denver, Denver, Colo.
Stephen GroshongDepartment of Medicine, Division of Allergy & Immunology, and Division of Pulmonary and Critical Care Medicine, National Jewish Health, Denver, Colo; School of Medicine, University of Colorado Denver, Denver, Colo.
Magdalena M GorskaDepartment of Medicine, Division of Allergy & Immunology, and Division of Pulmonary and Critical Care Medicine, National Jewish Health, Denver, Colo; School of Medicine, University of Colorado Denver, Denver, Colo.
Richard J MartinDepartment of Medicine, Division of Allergy & Immunology, and Division of Pulmonary and Critical Care Medicine, National Jewish Health, Denver, Colo; School of Medicine, University of Colorado Denver, Denver, Colo.
Rafeul AlamDepartment of Medicine, Division of Allergy & Immunology, and Division of Pulmonary and Critical Care Medicine, National Jewish Health, Denver, Colo; School of Medicine, University of Colorado Denver, Denver, Colo. Electronic address: alamr@njhealth.org.
University of Colorado Denver · USNational Jewish Health · US

Funding

Asthma susceptibility due to environmental programming of innate immunity in uteroR01HL122995 · NHLBI · NATIONAL JEWISH HEALTH · PI GORSKA, MAGDALENA MARIA · 2015 to 2024
$5.2M
Role of MEK1 in T cell function in asthmaR01AI091614 · NIAID · NATIONAL JEWISH HEALTH · PI ALAM, RAFEUL · 2011 to 2015
$2.0M
Airway Th2Th17 Cells in Refractory AsthmaR01HL126895 · NHLBI · NATIONAL JEWISH HEALTH · PI ALAM, RAFEUL · 2016 to 2019
$1.8M
Sprouty-2 Regulation of Signaling in AsthmaR01AI102943 · NIAID · NATIONAL JEWISH HEALTH · PI ALAM, RAFEUL · 2014 to 2017
$1.6M
NHLBI NIH HHS R01 HL122995NHLBI NIH HHS R01 HL126895NIAID NIH HHS R01 AI091614NIAID NIH HHS R01 AI102943
6 · The paper itself

Abstract

backgroundThe mechanism of T

objectiveWe sought to study the immune mechanism of T

methodsIn a previously reported cohort of 60 asthmatic patients, 16 patients were immunophenotyped with T

resultsPatients with T

conclusionWe uncovered a critical role for the IL-1β pathway in patients with T

Indexed as

AsthmaBronchoalveolar Lavage FluidCell LineCells, CulturedComplement C3aCytokinesEpithelial CellsHumansLeukocyte CountLipopolysaccharidesNeutrophilsp38 Mitogen-Activated Protein KinasesSerum Amyloid A ProteinTh17 CellsTh2 CellsComplement C3aCytokinesLipopolysaccharidesp38 Mitogen-Activated Protein KinasesSerum Amyloid A ProteinAsthma endotypeC3aIL-1infectionneutrophilic asthmaT(H)2/T(H)17-predominant asthma

Identifiers

PMID27702673
PMCPMC5376378
OpenAlexW2528730307

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.