Evidence map›Paper›PMID 27702409›Full record

SynthesisPublic health nutrition2017

The relationship between micronutrient status and sleep patterns: a systematic review.

Xiaopeng Ji, Michael A Grandner, Jianghong Liu

Open access · bronzeAbstract readSystematic Review
In one paragraph

Synthesis in Public health nutrition, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed, 3 pooled it
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 3 syntheses or guidelines pooled it, 99 citations in OpenAlex.

  1. Pooled it
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  8. Association of vitamin D and B12 levels with actigraphic sleep in cognitively unimpaired middle-aged and older adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026
    Article
  9. Association Between Serum Trace Elements and Obstructive Sleep Apnea in Iranian Adults: Multiple-exposure Models.Journal of preventive medicine and public health = Yebang Uihakhoe chi · 2026
    Article
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  11. Review
  12. Total dairy consumption is associated with healthy sleep patterns in U.S. adults.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2026
    Article
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  14. Review
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  20. Eating behaviors and mental health among celiac patients, case-control study.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2025
    Article

6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Xiaopeng Ji1School of Nursing, University of Pennsylvania,418 Curie Blvd,Philadelphia,PA 19104,USA.
Michael A Grandner2Department of Psychiatry,University of ArizonaCollege of Medicine,Tucson,AZ,USA.
Jianghong Liu1School of Nursing, University of Pennsylvania,418 Curie Blvd,Philadelphia,PA 19104,USA.
University of Pennsylvania · USUniversity of Arizona · US

Funding

Cardiovascular and Metabolic Risk Factors Associated with Short Sleep DurationK23HL110216 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI GRANDNER, MICHAEL A · 2012 to 2016
$813k
Mechanisms that mediate the link between lead exposure and child behavior problemK02ES019878 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI LIU, JIANGHONG · 2011 to 2015
$656k
NHLBI NIH HHS K23 HL110216NIEHS NIH HHS K02 ES019878
6 · The paper itself

Abstract

objectiveTo review articles on the relationship of dietary and circulating micronutrients with sleep patterns, and to identify issues surrounding implications for future research and public health practice.

designA systematic review was conducted. PubMed, Embase and Scopus were searched through January 2016.

settingBoth experimental and observational studies were included. However, studies that focused on secondary sleep impairment due to comorbidities were excluded. SUBJECTS: Individuals in different age groups, from infants to older adults.

resultsA total of twenty-six articles were selected. In the articles reviewed, researchers generally supported a potential role of micronutrients, particularly Fe and Mg, in the development of sleep stages among infants and in reversing age-related alterations in sleep architecture in older adults. Micronutrient status has also been linked to sleep duration, with sleep duration positively associated with Fe, Zn and Mg levels, and negatively associated with Cu, K and vitamin B12 levels. The mechanisms underlying these relationships include the impact of micronutrients on excitatory/inhibitory neurotransmitters and the expression of circadian genes.

conclusionsAlthough the number of studies on the relationship between micronutrient status and sleep remains low, evidence has emerged that suggests a link between dietary/circulating micronutrients and sleep. Future research is needed to investigate the dose-dependent as well as the longitudinal relationships between micronutrient levels and human sleep across populations, test the interactions among micronutrients on sleep outcomes, and ultimately examine the clinical relevance of micronutrients on sleep health.

Indexed as

Nutritional StatusSleepAdolescentAdultChildChild, PreschoolHumansInfantMicronutrientsMiddle AgedSleep StagesYoung AdultMicronutrientsMicronutrientMineralSleepTrace elementVitamin

Identifiers

PMID27702409
PMCPMC5675071
OpenAlexW2560412394

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.