ArticlePloS one2016
Low-Grade Inflammation Is Associated with Susceptibility to Infection in Healthy Men: Results from the Danish Blood Donor Study (DBDS).
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- The effect of acute stress on salivary markers of inflammation: A systematic review and meta-analysis.Brain, behavior, and immunity · 2020Pooled it
- Tofacitinib as a maintenance therapy in patients with ulcerative colitis stratified by OCTAVE Sustain baseline Mayo endoscopic subscore.BMC gastroenterology · 2023Trial
- Exploring molecular links between obesity and osteoporosis: insights from in-silico analysis and mannose supplementation.Scientific reports · 2025Article
- Iron deficiency and infection risk in Danish blood donors.Transfusion · 2025Article
- The impact of comorbidities on the prognosis of patients with septic arthritis.Frontiers in medicine · 2025Review
- Ibrutinib enhances the bias of T cell responses towards staphylococcal superantigens sustaining inflammation in chronic lymphocytic leukaemia.Frontiers in immunology · 2025Article
- The healthy donor effect and survey participation, becoming a donor and donor career.Transfusion · 2023Article
- A Preliminary Study on Acute Otitis Media in Spanish Children with Late Dinner Habits.International journal of environmental research and public health · 2022Article
- Chronic inflammation markers and cytokine-specific autoantibodies in Danish blood donors with restless legs syndrome.Scientific reports · 2022Article
- Investigating Causal Relations between Genetic-Related Intermediate Endophenotype and Risk of Chronic Prostatitis: Mendelian Randomization Study.Oxidative medicine and cellular longevity · 2022Article
- Link between Viral Infections, Immune System, Inflammation and Diet.International journal of environmental research and public health · 2021Review
- Meta-inflammatory state and insulin resistance can improve after 10 weeks of combined all-extremity high-intensity interval training in sedentary overweight/obese females: a quasi-experimental study.Journal of diabetes and metabolic disorders · 2020Article
- Integrated single-cell analysis of multicellular immune dynamics during hyperacute HIV-1 infection.Nature medicine · 2020Article
- Reply to the Comment on: Subrat Khanal et al. The Repertoire of Adenovirus in Human Disease: The Innocuous to the Deadly.Biomedicines · 2019Article
- Article
- Effects of High-Intensity Interval and Moderate-Intensity Continuous Exercise on Inflammatory, Leptin, IgA, and Lipid Peroxidation Responses in Obese Males.Frontiers in physiology · 2018Article
- Inflammatory Biomarkers and Risk of Schizophrenia: A 2-Sample Mendelian Randomization Study.JAMA psychiatry · 2017Article
- The clinical utility of the immune status questionnaire as a marker of immune function among persons with schizophrenia.Science progressArticle
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe aim of this study was to examine whether low-grade inflammation (LGI) is associated with a subsequently increased risk of infection.
methodsWe included 15,754 healthy participants from the Danish Blood Donor Study, who completed a questionnaire on health-related items. LGI was defined as a C-reactive protein level between 3 and 10 mg/L. Infections were identified by ICD-10 codes in the Danish National Patient Register and ATC-codes in the Danish Prescription Register. Multivariable Cox proportional hazard analysis was used as the statistical model.
resultsDuring 53,302 person-years of observation, 571 participants were hospitalized for infection. Similarly, during 26,125 person-years of observation, 7,276 participants filled a prescription of antimicrobials. LGI was associated with increased risk of hospital-based treatment for infection only among men (hazard ratio = 1.60, 95% confidence interval (CI): 1.10-2.34) and specifically infections were abscesses and infections of the skin and subcutaneous tissue. Similarly, LGI was associated with the overall use of antimicrobials among men, and particularly with phenoxymethylpenicillin and broad-spectrum antimicrobials for treatment of urinary tract infections. The difference between men and women was not statistically significant.
conclusionsIn a large cohort of healthy individuals, LGI was associated with an increased risk of infection among healthy male blood donors.
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