Evidence map›Paper›PMID 27701386›Full record

ArticleBritish journal of cancer2016

Reproductive history and risk of colorectal adenocarcinoma in parous women: a Nordic population-based case-control study.

Tone Bjørge, Mika Gissler, Anne Gulbech Ording, Anders Engeland, Ingrid Glimelius, Maarit Leinonen, Henrik Toft Sørensen, Steinar Tretli, Anders Ekbom, Rebecca Troisi and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of cancer, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Gravida and Birth Outcomes Prior to and after Diagnosis of Early Age-Onset Colorectal Cancer among Female Patients: Population-Based Epidemiologic Studies.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025
    Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 5 countries.

Tone BjørgeDepartment of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.
Mika GisslerNational Institute for Health and Welfare (THL), Helsinki, Finland.
Anne Gulbech OrdingDepartment of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.
Anders EngelandDepartment of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.
Ingrid GlimeliusDepartment of Medicine, Clinical Epidemiology Unit, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.
Maarit LeinonenCancer Society of Finland, Finnish Cancer Registry, Helsinki, Finland.
Henrik Toft SørensenDepartment of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.
Steinar TretliCancer Registry of Norway, Oslo, Norway.
Anders EkbomDepartment of Medicine, Clinical Epidemiology Unit, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.
Rebecca TroisiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA.
Tom GrotmolCancer Registry of Norway, Oslo, Norway.
Cancer Registry of Norway · NOAarhus University Hospital · DKKarolinska Institutet · SECancer Society of Finland · FIFinnish Institute for Health and Welfare · FINational Institutes of Health · USUniversity of Bergen · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundData are conflicting regarding the role of endogenous sex hormones in colorectal carcinogenesis. In this large population-based study, we pooled data from birth and cancer registries in four Nordic countries, to evaluate the risk of colorectal adenocarcinoma in relation to women's reproductive history.

methodsWe conducted a population-based case-control study among women registered in Nordic birth registries. The study included colorectal adenocarcinoma cases diagnosed in Denmark, Finland, Norway, and Sweden during 1967-2013 and up to 10 matched controls per case, in total 22 185 cases and 220 246 controls. Odds ratios (ORs) with 95% confidence intervals (95% CIs) were derived from conditional logistic regression models. We had limited information available on possible confounders.

resultsWe found no evidence for associations between colorectal adenocarcinoma and parity, age at first and last birth, and time since first and last birth. The risk estimates were also close to unity for specific cancer subsites (proximal and distal colon and rectum). As well, when the analyses were stratified on menopausal status, parity, and mother's year of birth, no indication of associations was found.

conclusionsIn this large, Nordic population-based study, no evidence for associations was found between women's reproductive history and colorectal adenocarcinoma in parous women.

Indexed as

ParityPopulation SurveillanceAdenocarcinomaAdultAgedCase-Control StudiesColorectal NeoplasmsFemaleGonadal Steroid HormonesHumansMiddle AgedPregnancyRisk FactorsScandinavian and Nordic CountriesGonadal Steroid Hormones

Identifiers

PMID27701386
PMCPMC5129816
OpenAlexW2528498741

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.