Evidence map›Paper›PMID 27701378›Full record

ArticleNature communications2016

Donor and host photoreceptors engage in material transfer following transplantation of post-mitotic photoreceptor precursors.

R A Pearson, A Gonzalez-Cordero, E L West, J R Ribeiro, N Aghaizu, D Goh, R D Sampson, A Georgiadis, P V Waldron, Y Duran and 8 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03437759 (Mesenchymal Stem Cells Derived Exosomes Promote Healing of Large and Refractory Macular Holes), which is not on this map. Cited by 187 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
187citing papers in PubMed, 2 pooled it
19.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03437759 early_phase1unknown statusnot on this mapstarted 2017, after this paper: background citation

Mesenchymal Stem Cells Derived Exosomes Promote Healing of Large and Refractory Macular Holes

TypeinterventionalSponsorTianjin Medical UniversityRan2017 to 2021Enrolled44ConditionsMacular HolesArmsexosomes derived from mesenchymal stem cells (MSC-Exo)
3 · Its place in the literature

Who cites it

187 citing papers in PubMed, 2 syntheses or guidelines pooled it, 315 citations in OpenAlex.

  1. Pooled it
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  17. The neuroimmune interface in retinal regeneration.Progress in retinal and eye research · 2025
    Review
  18. Animal models for the evaluation of retinal stem cell therapies.Progress in retinal and eye research · 2025
    Review
  19. Article
  20. Article

127 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 1 institution in 1 country.

R A PearsonDepartment of Genetics, University College London Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK.
A Gonzalez-CorderoDepartment of Genetics, University College London Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK.
E L WestDepartment of Genetics, University College London Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK.
J R RibeiroDepartment of Genetics, University College London Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK.
N AghaizuDepartment of Genetics, University College London Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK.
D GohDepartment of Genetics, University College London Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK.
R D SampsonDepartment of Genetics, University College London Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK.
A GeorgiadisDepartment of Genetics, University College London Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK.
P V WaldronDepartment of Genetics, University College London Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK.
Y DuranDepartment of Genetics, University College London Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK.
A NaeemDepartment of Genetics, University College London Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK.
M KlocDepartment of Genetics, University College London Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK.
E CristanteDepartment of Genetics, University College London Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK.
K KruczekDepartment of Genetics, University College London Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK.
K Warre-CornishDepartment of Genetics, University College London Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK.
J C SowdenStem Cells and Regenerative Medicine Section, 30 Guilford Street, London WC1N 1EH, UK.
A J SmithDepartment of Genetics, University College London Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK.
R R AliDepartment of Genetics, University College London Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK.
University College London · GB

Funding

European Research CouncilMedical Research Council MR/J004553/1Medical Research Council MR/L012758/1Medical Research Council MR/L022699/1Medical Research Council MR/M015688/1Wellcome Trust
6 · The paper itself

Abstract

Photoreceptor replacement by transplantation is proposed as a treatment for blindness. Transplantation of healthy photoreceptor precursor cells into diseased murine eyes leads to the presence of functional photoreceptors within host retinae that express an array of donor-specific proteins. The resulting improvement in visual function was understood to be due to donor cells integrating within host retinae. Here, however, we show that while integration occurs the majority of donor-reporter-labelled cells in the host arises as a result of material transfer between donor and host photoreceptors. Material transfer does not involve permanent donor-host nuclear or cell-cell fusion, or the uptake of free protein or nucleic acid from the extracellular environment. Instead, RNA and/or protein are exchanged between donor and host cells in vivo. These data require a re-evaluation of the mechanisms underlying rescue by photoreceptor transplantation and raise the possibility of material transfer as a strategy for the treatment of retinal disorders.

Indexed as

AnimalsFemaleGreen Fluorescent ProteinsMaleMiceMice, Inbred C57BLMicroscopy, ConfocalNIH 3T3 CellsPhotoreceptor Cells, VertebrateRetinaRetinal DegenerationRetinal DiseasesRetinal Rod Photoreceptor CellsRNAStem Cell TransplantationTissue DonorsGreen Fluorescent ProteinsRNA

Identifiers

PMID27701378
PMCPMC5059468
OpenAlexW2528283452

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.