Evidence map›Paper›PMID 27701114›Full record

ArticleScience (New York, N.Y.)2016

Instantaneous ion configurations in the K+ ion channel selectivity filter revealed by 2D IR spectroscopy.

Huong T Kratochvil, Joshua K Carr, Kimberly Matulef, Alvin W Annen, Hui Li, Michał Maj, Jared Ostmeyer, Arnaldo L Serrano, H Raghuraman, Sean D Moran and 5 more

Abstract read
In one paragraph

Article in Science (New York, N.Y.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers.

0numbers the graph read from it
0cells of the map it votes in
92citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

92 citing papers in PubMed.

  1. Molecular mechanisms of Kir channel gating.Biochemical Society transactions · 2026
    Review
  2. Article
  3. Article
  4. Article
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  6. Article
  7. Review
  8. Article
  9. Article
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  13. AI protocol for retrieving protein dynamic structures from two-dimensional infrared spectra.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  14. Article
  15. Article
  16. Do selectivity filter carbonyls in KJournal of structural biology: X · 2024
    Article
  17. Article
  18. Article
  19. Article
  20. Unraveling dynamic protein structures by two-dimensional infrared spectra with a pretrained machine learning model.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article

32 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Huong T KratochvilDepartment of Chemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.
Joshua K CarrDepartment of Chemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.
Kimberly MatulefProgram in Chemical Biology, Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, OR 97239, USA.
Alvin W AnnenProgram in Chemical Biology, Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, OR 97239, USA.
Hui LiDepartment of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL 60637, USA.
Michał MajDepartment of Chemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.
Jared OstmeyerDepartment of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL 60637, USA.
Arnaldo L SerranoDepartment of Chemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.
H RaghuramanDepartment of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL 60637, USA.
Sean D MoranDepartment of Chemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.
J L SkinnerDepartment of Chemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.
Eduardo PerozoDepartment of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL 60637, USA. eperozo@uchicago.edu roux@uchicago.edu valiyave@ohsu.edu zanni@chem.wisc.edu.
Benoît RouxDepartment of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL 60637, USA. eperozo@uchicago.edu roux@uchicago.edu valiyave@ohsu.edu zanni@chem.wisc.edu.
Francis I ValiyaveetilProgram in Chemical Biology, Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, OR 97239, USA. eperozo@uchicago.edu roux@uchicago.edu valiyave@ohsu.edu zanni@chem.wisc.edu.
Martin T ZanniDepartment of Chemistry, University of Wisconsin-Madison, Madison, WI 53706, USA. eperozo@uchicago.edu roux@uchicago.edu valiyave@ohsu.edu zanni@chem.wisc.edu.

Funding

Synthetic Antigen Binder CoreU54GM087519 · NIGMS · UNIVERSITY OF CHICAGO · PI ZHOU, MING · 2010 to 2017
$31.9M
Computational Studies of Ion Channels - Resubmission 01R01GM062342 · NIGMS · WEILL MEDICAL COLLEGE OF CORNELL UNIV · PI ROUX, BENOIT · 2001 to 2022
$8.7M
Structural mechanism of diabetic amyloid formationR01DK079895 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI Martin T Zanni · 2008 to 2026
$7.7M
HIGH RESOLUTION STRUCTURAL DYNAMICS OF K CHANNELSR01GM057846 · NIGMS · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI PEROZO, EDUARDO A · 1998 to 2018
$7.4M
Probing functional mechanisms in K+ channels using unnatural mutagenesisR01GM087546 · NIGMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI VALIYAVEETIL, FRANCIS · 2009 to 2022
$4.0M
NIDDK NIH HHS R01 DK079895NIGMS NIH HHS R01 GM057846NIGMS NIH HHS R01 GM062342NIGMS NIH HHS R01 GM087546NIGMS NIH HHS U54 GM087519
6 · The paper itself

Abstract

Potassium channels are responsible for the selective permeation of K

Indexed as

Models, ChemicalBacterial ProteinsBinding SitesCarbon IsotopesCrystallography, X-RayIsotope LabelingMolecular Dynamics SimulationOxygen IsotopesPotassium ChannelsProtein ConformationSodiumSpectrophotometry, InfraredWaterBacterial ProteinsCarbon IsotopesOxygen IsotopesPotassium Channelsprokaryotic potassium channelSodiumWater

Identifiers

PMID27701114
PMCPMC5544905

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.