Evidence map›Paper›PMID 27701074›Full record

ArticleNucleic acids research2017

CeNDR, the Caenorhabditis elegans natural diversity resource.

Daniel E Cook, Stefan Zdraljevic, Joshua P Roberts, Erik C Andersen

Abstract read
In one paragraph

Article in Nucleic acids research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 202 papers.

0numbers the graph read from it
0cells of the map it votes in
202citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

202 citing papers in PubMed.

  1. Article
  2. DivergenteLife · 2026
    Article
  3. Article
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  9. Article
  10. Review
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  12. Article
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  14. Evolution of developmental bias explains divergent patterns of phenotypic evolution in two nematode clades.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. The regulatory architecture of gene expression variation inbioRxiv : the preprint server for biology · 2025
    Article
  20. Intraspecific variation in the duration of epigenetic inheritance.bioRxiv : the preprint server for biology · 2025
    Article

142 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Daniel E CookInterdisciplinary Biological Sciences Program, Northwestern University, Evanston, IL 60208, USA.
Stefan ZdraljevicInterdisciplinary Biological Sciences Program, Northwestern University, Evanston, IL 60208, USA.
Joshua P RobertsDepartment of Molecular Biosciences, Northwestern University, Evanston, IL 60208, USA.
Erik C AndersenDepartment of Molecular Biosciences, Northwestern University, Evanston, IL 60208, USA Erik.Andersen@Northwestern.edu.ORCID 0000-0003-0229-9651

Funding

CELLULAR &MOLECULAR BASIS OF DISEASE TRAINING PROGRAMT32GM008061 · NIGMS · NORTHWESTERN UNIVERSITY · PI CARTHEW, RICHARD W. · 1985 to 2022
$17.1M
Determination of the distribution of fitness effects of mutations in C. elegansR01GM107227 · NIGMS · UNIVERSITY OF FLORIDA · PI BAER, CHARLES F · 2014 to 2017
$1.1M
NIGMS NIH HHS R01 GM107227NIGMS NIH HHS T32 GM008061
6 · The paper itself

Abstract

Studies in model organisms have yielded considerable insights into the etiology of disease and our understanding of evolutionary processes. Caenorhabditis elegans is among the most powerful model organisms used to understand biology. However, C. elegans is not used as extensively as other model organisms to investigate how natural variation shapes traits, especially through the use of genome-wide association (GWA) analyses. Here, we introduce a new platform, the C. elegans Natural Diversity Resource (CeNDR) to enable statistical genetics and genomics studies of C. elegans and to connect the results to human disease. CeNDR provides the research community with wild strains, genome-wide sequence and variant data for every strain, and a GWA mapping portal for studying natural variation in C. elegans Additionally, researchers outside of the C. elegans community can benefit from public mappings and integrated tools for comparative analyses. CeNDR uses several databases that are continually updated through the addition of new strains, sequencing data, and association mapping results. The CeNDR data are accessible through a freely available web portal located at http://www.elegansvariation.org or through an application programming interface.

Indexed as

BiodiversityDatabases, GeneticAnimalsCaenorhabditis elegansGenetic Association StudiesGenome-Wide Association StudyGenomicsSoftwareWeb Browser

Identifiers

PMID27701074
PMCPMC5210618

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.