SynthesisJournal of psychiatric research2017
A systematic review and secondary data analysis of the interactions between the serotonin transporter 5-HTTLPR polymorphism and environmental and psychological factors in eating disorders.
Synthesis in Journal of psychiatric research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Night Eating Syndrome in Patients With Obesity and Binge Eating Disorder: A Systematic Review.Frontiers in psychology · 2021Pooled it
- Insights into neuroscience from the representative birth cohort samples of a multidisciplinary longitudinal study.Acta neuropsychiatrica · 2026Review
- Molecular Mechanisms of Depression: The Interplay Between Genes and Receptors.International journal of molecular sciences · 2025Review
- Latent classes of mental health disorders and their associations with polymorphisms of 5HTTLPR and BDNF in a Chilean primary care population.Global mental health (Cambridge, England) · 2025Article
- Associations of the serotonin transporter gene polymorphism, 5-HTTLPR, and adverse life events with late life depression in the elderly Lithuanian population.Scientific reports · 2023Article
- Article
- Risk factors for eating disorders: findings from a rapid review.Journal of eating disorders · 2023Review
- Article
- Body-Related Attitudes, Personality, and Identity in Female Adolescents with Anorexia Nervosa or Other Mental Disorders.International journal of environmental research and public health · 2022Article
- Context matters: Neighborhood disadvantage is associated with increased disordered eating and earlier activation of genetic influences in girls.Journal of abnormal psychology · 2021Article
- Stressful life events among individuals with a history of eating disorders: a case-control comparison.BMC psychiatry · 2021Article
- Trauma-informed care and practice for eating disorders: personal and professional perspectives of lived experiences.Eating and weight disorders : EWD · 2019Article
- Role of eating disorders-related polymorphisms in obesity pathophysiology.Reviews in endocrine & metabolic disorders · 2019Review
- Individual biological sensitivity to environmental influences: testing the differential susceptibility properties of the 5HTTLPR polymorphism in relation to depressive symptoms and delinquency in two adolescent general samples.Journal of neural transmission (Vienna, Austria : 1996) · 2018Article
- Update on Psychological Trauma, Other Severe Adverse Experiences and Eating Disorders: State of the Research and Future Research Directions.Current psychiatry reports · 2017Review
- Investigating Direct Links between Depression, Emotional Control, and Physical Punishment with Adolescent Drive for Thinness and Bulimic Behaviors, Including Possible Moderation by the Serotonin TransporterFrontiers in psychology · 2017Article
Corrections and comments
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Authors and funding
21 authors at 13 institutions in 8 countries.
Funding
Abstract
objectivesTo summarize and synthesize the growing gene x environment (GxE) research investigating the promoter region of the serotonin transporter gene (5-HTTLPR) in the eating disorders (ED) field, and overcome the common limitation of low sample size, by undertaking a systematic review followed by a secondary data meta-analysis of studies identified by the review.
methodA systematic review of articles using PsycINFO, PubMed, and EMBASE was undertaken to identify studies investigating the interaction between 5-HTTLPR and an environmental or psychological factor, with an ED-related outcome variable. Seven studies were identified by the systematic review, with complete data sets of five community (n = 1750, 64.5% female) and two clinical (n = 426, 100% female) samples combined to perform four secondary-data analyses: 5-HTTLPR x Traumatic Life Events to predict ED status (n = 909), 5-HTTLPR x Sexual and Physical Abuse to predict bulimic symptoms (n = 1097), 5-HTTLPR x Depression to predict bulimic symptoms (n = 1256), and 5-HTTLPR x Impulsiveness to predict disordered eating (n = 1149).
resultsUnder a multiplicative model, the low function (s) allele of 5-HTTLPR interacted with traumatic life events and experiencing both sexual and physical abuse (but not only one) to predict increased likelihood of an ED and bulimic symptoms, respectively. However, under an additive model there was also an interaction between sexual and physical abuse considered independently and 5-HTTLPR, and no interaction with traumatic life events. No other GxE interactions were significant.
conclusionEarly promising results should be followed-up with continued cross-institutional collaboration in order to achieve the large sample sizes necessary for genetic research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.