ArticleeLife2016
Stochasticity in the miR-9/Hes1 oscillatory network can account for clonal heterogeneity in the timing of differentiation.
Article in eLife, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Efficient approximations of transcriptional bursting effects on the dynamics of a gene regulatory network.Journal of the Royal Society, Interface · 2025Article
- Modelling Population-Level Hes1 Dynamics: Insights from a Multi-framework Approach.Bulletin of mathematical biology · 2025Article
- Relaxation and Noise-Driven Oscillations in a Model of Mitotic Spindle Dynamics.Bulletin of mathematical biology · 2024Article
- Sequential and additive expression of miR-9 precursors control timing of neurogenesis.Development (Cambridge, England) · 2022Article
- Nonmodular oscillator and switch based on RNA decay drive regeneration of multimodal gene expression.Nucleic acids research · 2022Article
- Differential phase register of Hes1 oscillations with mitoses underlies cell-cycle heterogeneity in ERProceedings of the National Academy of Sciences of the United States of America · 2021Article
- HES1 protein oscillations are necessary for neural stem cells to exit from quiescence.iScience · 2021Article
- Inferring kinetic parameters of oscillatory gene regulation from single cell time-series data.Journal of the Royal Society, Interface · 2021Article
- A dynamic, spatially periodic, micro-pattern of HES5 underlies neurogenesis in the mouse spinal cord.Molecular systems biology · 2021Article
- smiFISH and embryo segmentation for single-cell multi-gene RNA quantification in arthropods.Communications biology · 2021Article
- Dynamic properties of noise and Her6 levels are optimized by miR-9, allowing the decoding of the Her6 oscillator.The EMBO journal · 2020Article
- Order Through Disorder: The Characteristic Variability of Systems.Frontiers in cell and developmental biology · 2020Review
- Intrinsic noise, Delta-Notch signalling and delayed reactions promote sustained, coherent, synchronized oscillations in the presomitic mesoderm.Journal of the Royal Society, Interface · 2019Article
- Quantitative single-cell live imaging links HES5 dynamics with cell-state and fate in murine neurogenesis.Nature communications · 2019Article
- Noise in the Vertebrate Segmentation Clock Is Boosted by Time Delays but Tamed by Notch Signaling.Cell reports · 2018Article
- Stochastic loss and gain of symmetric divisions in the C. elegans epidermis perturbs robustness of stem cell number.PLoS biology · 2017Article
- Identifying stochastic oscillations in single-cell live imaging time series using Gaussian processes.PLoS computational biology · 2017Article
- Notch/Hes signaling and miR-9 engage in complex feedback interactions controlling neural progenitor cell proliferation and differentiation.Neurogenesis (Austin, Tex.) · 2017Review
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
Recent studies suggest that cells make stochastic choices with respect to differentiation or division. However, the molecular mechanism underlying such stochasticity is unknown. We previously proposed that the timing of vertebrate neuronal differentiation is regulated by molecular oscillations of a transcriptional repressor, HES1, tuned by a post-transcriptional repressor, miR-9. Here, we computationally model the effects of intrinsic noise on the
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.