Evidence map›Paper›PMID 27700118›Full record

ArticleThe journal of physical chemistry. B2017

Origin of pK

Xiongwu Wu, Juyong Lee, Bernard R Brooks

Abstract read
In one paragraph

Article in The journal of physical chemistry. B, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Protein pJournal of chemical theory and computation · 2022
    Article
  3. Article
  4. Article
  5. Threats to adhesive/dentin interfacial integrity and next generation bio-enabled multifunctional adhesives.Journal of biomedical materials research. Part B, Applied biomaterials · 2019
    Review
  6. Modulating pH through lysine integrated dental adhesives.Dental materials : official publication of the Academy of Dental Materials · 2018
    Article
  7. Reservoir pH replica exchange.The Journal of chemical physics · 2018
    Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Xiongwu WuLaboratory of Computational Biology, National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH) , Bethesda, Maryland 20892, United States.
Juyong LeeLaboratory of Computational Biology, National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH) , Bethesda, Maryland 20892, United States.
Bernard R BrooksLaboratory of Computational Biology, National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH) , Bethesda, Maryland 20892, United States.
National Institutes of Health · USNational Heart Lung and Blood Institute · US

Funding

Development Of Theoretical Methods For Studying Biological MacromoleculesZIAHL001051 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI BROOKS, BERNARD R · 2009 to 2025
$16.2M
Molecular Dynamics Simulations Of Biological MacromoleculesZIAHL001050 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI BROOKS, BERNARD R · 2009 to 2025
$12.9M
Three-dimensional Structures Of Biological MacromoleculesZIAHL001027 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI BROOKS, BERNARD R · 2009 to 2025
$8.1M
Molecular Dynamics Simulations of MacromoleculesZ01HL001050 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI BROOKS, BERNARD R · 1998 to 2008
$1.4M
Intramural NIH HHS Z01 HL001050Intramural NIH HHS Z99 HL999999Intramural NIH HHS ZIA HL001027Intramural NIH HHS ZIA HL001050
6 · The paper itself

Abstract

Protein internal ionizable groups can exhibit large shifts in pK

Indexed as

Molecular Dynamics SimulationThermodynamicsHydrogen-Ion ConcentrationLysineMicrococcal NucleaseWaterLysineMicrococcal NucleaseWater

Identifiers

PMID27700118
PMCPMC6415756
OpenAlexW2529058225

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.