Evidence map›Paper›PMID 27700049›Full record

ArticleACS chemical neuroscience2016

Pharmacodynamic Relationships between Duration of Action of JDTic-like Kappa-Opioid Receptor Antagonists and Their Brain and Plasma Pharmacokinetics in Rats.

S Michael Owens, Gerald T Pollard, James L Howard, Timothy R Fennell, Rodney W Snyder, F Ivy Carroll

Open access · greenAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS chemical neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Evaluation of Specific Binding of [ACS medicinal chemistry letters · 2021
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

S Michael OwensUniversity of Arkansas for Medical Sciences , College of Medicine, Department of Pharmacology and Toxicology, Little Rock, Arkansas 72205, United States.
Gerald T PollardHoward Associates, LLC , 3040 East Cornwallis Road, P.O. Box 12194, Research Triangle Park, North Carolina 27709-2194, United States.
James L HowardHoward Associates, LLC , 3040 East Cornwallis Road, P.O. Box 12194, Research Triangle Park, North Carolina 27709-2194, United States.
Timothy R FennellResearch Triangle Institute , 3040 East Cornwallis Road, P.O. Box 12194, Research Triangle Park, North Carolina 27709-2194, United States.
Rodney W SnyderResearch Triangle Institute , 3040 East Cornwallis Road, P.O. Box 12194, Research Triangle Park, North Carolina 27709-2194, United States.
F Ivy CarrollResearch Triangle Institute , 3040 East Cornwallis Road, P.O. Box 12194, Research Triangle Park, North Carolina 27709-2194, United States.
RTI International · USResearch Triangle Park Foundation · USUniversity of Arkansas for Medical Sciences · US

Funding

Selective Opioid Antagonists as Medications for Drug AbuseR01DA009045 · NIDA · RESEARCH TRIANGLE INSTITUTE · PI CARROLL, FRANK IVY · 1994 to 2014
$5.6M
NIDA NIH HHS R01 DA009045
6 · The paper itself

Abstract

JDTic is a potent and selective κ-opioid receptor (KOR) antagonist that reverses U50,488-induced diuresis in rats. It partitions into brain with a duration of action lasting for weeks. In a search for KOR antagonists that do not accumulate in the brain, we compared single doses of five methylated JDTic analogs (RTI-97, -194, -212, -240, and -241) for reversal of U50,488 diuresis and pharmacokinetic (PK) properties. All six compounds showed potent and selective KOR antagonism in a [

Indexed as

3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-IsomerAnimalsArea Under CurveBrainDiureticsGuanosine 5'-O-(3-Thiotriphosphate)HumansMaleMolecular StructureNarcotic AntagonistsPiperidinesProtein BindingRats, Sprague-DawleyReceptors, Opioid, deltaReceptors, Opioid, kappaReceptors, Opioid, mu3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer7-hydroxy-N-(1-((4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl)methyl)-2-methylpropyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide7-hydroxy-N-(1-((4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl)methyl)-2-methylbutyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide dihydrochlorideDiureticsGuanosine 5'-O-(3-Thiotriphosphate)Narcotic AntagonistsPiperidinesReceptors, Opioid, deltaReceptors, Opioid, kappaReceptors, Opioid, muTetrahydroisoquinolinesbraindiuresisJDTicpharmacokineticsprodrugratκ-opioid receptor antagonist

Identifiers

PMID27700049
PMCPMC6532972
OpenAlexW2522147099

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.