ArticleEndocrine2017
Heterogeneity in glucose response curves during an oral glucose tolerance test and associated cardiometabolic risk.
Article in Endocrine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Use of Metabotyping to Identify Individuals With Different Triglyceride Response Curves After Intake of High-Fat Meals.Molecular nutrition & food research · 2026Trial
- Trial
- Positive impact of a 10-min walk immediately after glucose intake on postprandial glucose levels.Scientific reports · 2025Trial
- Inflammatory Proteomic Heterogeneity Beyond Glycemia Status in Severe Obesity.International journal of molecular sciences · 2026Article
- Article
- Methylglyoxal Mediates the Association Between 2-Hour Plasma Glucose and HbA1c With Inflammation: The Maastricht Study.The Journal of clinical endocrinology and metabolism · 2025Article
- Association between early-stage diabetic nephropathy and the delayed monophasic glucose peak during oral glucose tolerance test in type 2 diabetes mellitus.Journal of diabetes investigation · 2025Observational
- Mechanistic Insights Into the Heterogeneity of Glucose Response Classes in Youths With Obesity: A Latent Class Trajectory Approach.Diabetes care · 2022Article
- The characteristics of postprandial glycemic response patterns to white rice and glucose in healthy adults: Identifying subgroups by clustering analysis.Frontiers in nutrition · 2022Article
- Oral glucose tolerance test in diabetes, the old method revisited.World journal of diabetes · 2021Review
- Review of methods for detecting glycemic disorders.Diabetes research and clinical practice · 2020Review
- Different physiological mechanisms underlie an adverse cardiovascular disease risk profile in men and women.The Proceedings of the Nutrition Society · 2020Review
- Article
- The Oral Glucose Tolerance Test: 100 Years Later.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Review
- The Effect of Prior Gestational Diabetes on the Shape of the Glucose Response Curve during an Oral Glucose Tolerance Test 3 Years after Delivery.Journal of diabetes research · 2020Article
- Post-load glucose subgroups and associated metabolic traits in individuals with type 2 diabetes: An IMI-DIRECT study.PloS one · 2020Article
- The oral glucose tolerance test-derived incremental glucose peak is associated with greater arterial stiffness and maladaptive arterial remodeling: The Maastricht Study.Cardiovascular diabetology · 2019Observational
- Clusters of Glycemic Response to Oral Glucose Tolerance Tests Explain Multivariate Metabolic and Anthropometric Outcomes of Bariatric Surgery in Obese Patients.Journal of clinical medicine · 2019Article
- Glucose patterns during an oral glucose tolerance test and associations with future diabetes, cardiovascular disease and all-cause mortality rate.Diabetologia · 2018Article
- Time to glucose peak during an oral glucose tolerance test identifies prediabetes risk.Clinical endocrinology · 2017Article
Corrections and comments
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Authors and funding
19 authors.
Funding
Abstract
We aimed to examine heterogeneity in glucose response curves during an oral glucose tolerance test with multiple measurements and to compare cardiometabolic risk profiles between identified glucose response curve groups. We analyzed data from 1,267 individuals without diabetes from five studies in Denmark, the Netherlands and the USA. Each study included between 5 and 11 measurements at different time points during a 2-h oral glucose tolerance test, resulting in 9,602 plasma glucose measurements. Latent class trajectories with a cubic specification for time were fitted to identify different patterns of plasma glucose change during the oral glucose tolerance test. Cardiometabolic risk factor profiles were compared between the identified groups. Using latent class trajectory analysis, five glucose response curves were identified. Despite similar fasting and 2-h values, glucose peaks and peak times varied greatly between groups, ranging from 7-12 mmol/L, and 35-70 min. The group with the lowest and earliest plasma glucose peak had the lowest estimated cardiovascular risk, while the group with the most delayed plasma glucose peak and the highest 2-h value had the highest estimated risk. One group, with normal fasting and 2-h values, exhibited an unusual profile, with the highest glucose peak and the highest proportion of smokers and men. The heterogeneity in glucose response curves and the distinct cardiometabolic risk profiles may reflect different underlying physiologies. Our results warrant more detailed studies to identify the source of the heterogeneity across the different phenotypes and whether these differences play a role in the development of type 2 diabetes and cardiovascular disease.
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Registered trials
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