Evidence map›Paper›PMID 27699594›Full record

ArticleAIDS and behavior2017

Objective Measurement of Inaccurate Condom Use Reporting Among Women Using Depot Medroxyprogesterone Acetate for Contraception.

Renee Heffron, Urvi M Parikh, Kerri J Penrose, Nelly Mugo, Deborah Donnell, Connie Celum, John W Mellors, Jared M Baeten, Partners PrEP Study Team

Abstract read
In one paragraph

Article in AIDS and behavior, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Renee HeffronDepartment of Global Health, University of Washington, 325 Ninth Avenue, Box 359927, Seattle, WA, 98104, USA. rheffron@uw.edu.ORCID http://orcid.org/0000-0001-6039-0352
Urvi M ParikhDepartment of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Kerri J PenroseDepartment of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Nelly MugoDepartment of Global Health, University of Washington, 325 Ninth Avenue, Box 359927, Seattle, WA, 98104, USA.
Deborah DonnellDepartment of Global Health, University of Washington, 325 Ninth Avenue, Box 359927, Seattle, WA, 98104, USA.
Connie CelumDepartment of Global Health, University of Washington, 325 Ninth Avenue, Box 359927, Seattle, WA, 98104, USA.
John W MellorsDepartment of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Jared M BaetenDepartment of Global Health, University of Washington, 325 Ninth Avenue, Box 359927, Seattle, WA, 98104, USA.
Partners PrEP Study Team
University of Pittsburgh · USUniversity of Washington · USInfectious Disease Research Institute · US

Funding

Antiretroviral periconception HIV prevention for HIV discordant couplesR00HD076679 · NICHD · UNIVERSITY OF WASHINGTON · PI HEFFRON, RENEE A. · 2015 to 2017
$742k
Hormonal contraception, pre-exposure prophylaxis, and HIV-1 protectionR21HD074439 · NICHD · UNIVERSITY OF WASHINGTON · PI BAETEN, JARED · 2013 to 2014
$432k
NICHD NIH HHS R00 HD076679NICHD NIH HHS R21 HD074439
6 · The paper itself

Abstract

Observational analyses have suggested that women using the injectable contraceptive depot medroxyprogesterone acetate (DMPA) may have heightened risk of acquiring HIV. However, those analyses were potentially confounded by sexual behavior, with possible differential condom use and reporting by women using DMPA versus no contraception. In a cross-sectional study, we measured the presence of a biomarker of recent condomless sex (Y chromosomal [Yc] DNA) in vaginal swabs from HIV-uninfected African women who had an HIV-infected partner and reported 100 % condom use. Half of the samples tested were from women reporting DMPA and half were from women using no contraception. Among 428 specimens tested (213 from DMPA users and 215 from women using no contraception), 32.0 % had Yc DNA detected, with a mean of 193 copies/10,000 human cells (range 0.1-8201). The frequency of detection did not differ by contraceptive use: 34.2 % of DMPA users versus 29.8 % of women using no contraception, adjusted odds ratio 1.3 (95 % confidence interval 0.9-2.0). These results suggest that inaccurate reporting of condom use by DMPA users may not account for the heightened risk of HIV acquisition among DMPA users in some observational studies.

Indexed as

AdultCase-Control StudiesChromosomes, Human, YCondomsContraception BehaviorContraceptive Agents, FemaleCross-Sectional StudiesDelayed-Action PreparationsDNAFemaleHIV InfectionsHumansMedroxyprogesterone AcetateOdds RatioRiskSexual BehaviorContraceptive Agents, FemaleDelayed-Action PreparationsDNAMedroxyprogesterone AcetateAfricaBiomarkerCondomsDMPAHIVY chromosomal DNA

Identifiers

PMID27699594
PMCPMC5378697
OpenAlexW2529290094

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.