ArticleJournal of neurology2016
Vascular comorbidities in multiple sclerosis: a nationwide study from Denmark.
Article in Journal of neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Prevalence and epidemiology of stroke in patients with multiple sclerosis: a systematic review and meta-analysis.Journal of neurology · 2024Pooled it
- Association between systemic sclerosis and risk of cerebrovascular and cardiovascular disease: a meta-analysis.Scientific reports · 2024Pooled it
- Multiple sclerosis and stroke: a systematic review and meta-analysis.BMC neurology · 2019Pooled it
- E-based physical exercise in patients with multiple sclerosis and comorbidity (COMPACT): feasibility study and protocol for a randomized controlled trial.Frontiers in immunology · 2026Trial
- Vascular risk factors are associated with grey matter atrophy in secondary progressive multiple sclerosis.European journal of neurology · 2025Trial
- Comorbidity and modifiable risk factors in multiple sclerosis.Therapeutic advances in neurological disorders · 2026Review
- Investigating the treatment of vascular risk with simvastatin in secondary progressive multiple sclerosis: analysis from the MS-STAT2 randomized controlled trial.Brain communications · 2026Article
- Clusters of Comorbidities in Multiple Sclerosis and Their Influence on Healthcare Resource Usage.European journal of neurology · 2025Observational
- Review
- Association of multiple sclerosis with stroke: A comprehensive review.Health science reports · 2024Article
- Subclinical atherosclerosis in patients with relapsing-remitting multiple sclerosis.Wiener klinische Wochenschrift · 2024Article
- Retinal Blood Vessel Analysis Using Optical Coherence Tomography (OCT) in Multiple Sclerosis.Diagnostics (Basel, Switzerland) · 2023Article
- Comorbidity in the aging population with multiple sclerosis: a Danish nationwide study.Frontiers in neurology · 2023Article
- Immune aging in multiple sclerosis is characterized by abnormal CD4 T cell activation and increased frequencies of cytotoxic CD4 T cells with advancing age.EBioMedicine · 2022Article
- Multiple Sclerosis and the Risk of Cardiovascular Diseases: A Mendelian Randomization Study.Frontiers in immunology · 2022Article
- The Danish Multiple Sclerosis Registry.Brain and behavior · 2021Article
- Comorbidity in Multiple Sclerosis.Frontiers in neurology · 2020Review
- Unique RNA signature of different lesion types in the brain white matter in progressive multiple sclerosis.Acta neuropathologica communications · 2019Article
- Dietary and lifestyle factors in multiple sclerosis progression: results from a 5-year longitudinal MRI study.Journal of neurology · 2019Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To investigate the occurrence of vascular comorbidities before and after the clinical onset of multiple sclerosis. In this combined case-control and cohort study, all Danish born citizens with onset of multiple sclerosis 1980-2005 were identified from the Danish Multiple Sclerosis Registry and randomly matched with controls regarding year of birth, gender, and municipality on January 1st in the year of multiple sclerosis (MS) onset (index date). Individual-level information on comorbidities was obtained from several independent nationwide registries and linked to the study population by unique personal identification numbers. To assess the presence of vascular comorbidities before and after MS onset, cases and controls were followed from January 1977 to the index date, and from the index date through December 2012. We used logistic regression to calculate odds ratios (ORs) and Cox regression to calculate hazard ratios (HRs). Before the index date, MS cases had a decreased probability for cerebrovascular comorbidity [OR 0.69 (95 % CI 0.48-0.99, p = 0.043)], and a numerically but not statistically significant decreased probability for cardiovascular comorbidity [OR 0.87 (95 % CI 0.71-1.07, p = 0.188)]. After the index date, MS cases had an increased risk for cerebrovascular comorbidity [HR 1.84 (95 % CI 1.69-2.00, p < 0.0005)], and for cardiovascular comorbidity [HR 1.08 (95 % CI 1.02-1.15, p = 0.013)]. The lower occurrence of cerebrovascular comorbidities in cases prior to MS onset could be due to protective immune mechanisms, while the higher occurrence of vascular comorbidities in cases after MS onset could be because of converging causal pathways of the coexisting diseases. These findings deserve to be studied closer in a broader spectrum of comorbidities in MS.
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Registered trials
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