ArticleInvestigative ophthalmology & visual science2016
In Vivo Brillouin Analysis of the Aging Crystalline Lens.
Article in Investigative ophthalmology & visual science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed, 92 citations in OpenAlex.
- In vivo elastography of the human retina using light-evoked intrinsic actuation.bioRxiv : the preprint server for biology · 2026Article
- Molecular and Biomechanical Changes in the Anterior Segment of High Myopic Eyes.Annals of biomedical engineering · 2026Review
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- Clinical multimodal Brillouin microscopy-optical coherence elastography system for lens biomechanics.Journal of biomedical optics · 2025Article
- Optical Coherence Elastography Measures Mechanical Tension in the Lens and Capsule.Acta biomaterialia · 2025Article
- In Vivo Brillouin Analysis of Lens Nucleus and Cortex in Adult Myopic Eyes and Their Correlation With Accommodation.Investigative ophthalmology & visual science · 2025Article
- Ex Vivo Microsuturing of the Human Anterior Lens Capsule Using 10-0 Sutures: A Technical Feasibility Report.Cureus · 2025Article
- Article
- Brillouin Metrics of the Crystalline Lens Comparison Between Low-Medium Myopia and High Myopia.Clinical ophthalmology (Auckland, N.Z.) · 2025Article
- Comparative analysis of rodent lens morphometrics and biomechanical properties.Frontiers in ophthalmology · 2025Article
- Optical coherence tomography quantifies gradient refractive index and mechanical stiffness gradient across the human lens.Communications medicine · 2024Article
- The Effect of the Zonular Fiber Angle of Insertion on Accommodation.Vision (Basel, Switzerland) · 2024Article
- Functional effects of the spatial-varying lens mechanical properties in accommodation.JPhys photonics · 2024Article
- Model of zonular forces on the lens capsule during accommodation.Scientific reports · 2024Article
- The potential influence of the ligament of Wieger on the crystalline lens shape.Scientific reports · 2024Article
- Brillouin microscopy.Nature reviews. Methods primers · 2024Article
- Storage-induced mechanical changes of porcine lenses assessed with optical coherence elastography and inverse finite element modeling.Frontiers in bioengineering and biotechnology · 2024Article
- Age-related changes in geometry and transparency of human crystalline lens revealed by optical signal discontinuity zones in swept-source OCT images.Eye and vision (London, England) · 2023Article
- Multimodal diagnostics for keratoconus and ectatic corneal diseases: a paradigm shift.Eye and vision (London, England) · 2023Review
- Estimation of Crystalline Lens Material Properties From Patient Accommodation Data and Finite Element Models.Investigative ophthalmology & visual science · 2023Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
purposeTo analyze the age dependence of the longitudinal modulus of the crystalline lens in vivo using Brillouin scattering data in healthy subjects.
methodsBrillouin scans were performed along the crystalline lens in 56 eyes from 30 healthy subjects aged from 19 to 63 years. Longitudinal elastic modulus was acquired along the sagittal axis of the lens with a transverse and axial resolution of 4 and 60 μm, respectively. The relative lens stiffness was computed, and correlations with age were analyzed.
resultsBrillouin axial profiles revealed nonuniform longitudinal modulus within the lens, increasing from a softer periphery toward a stiffer central plateau at all ages. The longitudinal modulus at the central plateau showed no age dependence in a range of 19 to 45 years and a slight decrease with age from 45 to 63 years. A significant intersubject variability was observed in an age-matched analysis. Importantly, the extent of the central stiff plateau region increased steadily over age from 19 to 63 years. The slope of change in Brillouin modulus in the peripheral regions were nearly age-invariant.
conclusionsThe adult human lens showed no measurable age-related increase in the peak longitudinal modulus. The expansion of the stiff central region of the lens is likely to be the major contributing factor to age-related lens stiffening. Brillouin microscopy may be useful in characterizing the crystalline lens for the optimization of surgical or pharmacological treatments aimed at restoring accommodative power.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.