ArticleJCI insight2016
Cell-type deconvolution with immune pathways identifies gene networks of host defense and immunopathology in leprosy.
Article in JCI insight, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 33 citations in OpenAlex.
- Identification of a spatially organized TREM2-associated permissive macrophage niche in human pulmonary tuberculosis alveolar pneumonia.Nature communications · 2026Article
- Contribution of cytotoxic CD8 T cells, neutrophils and type 1 interferon signaling to hyperinflammation in HIV-associated TB meningitis.bioRxiv : the preprint server for biology · 2026Article
- Whole blood transcriptomics reveals the enrichment of neutrophil activation pathways during erythema nodosum leprosum reaction.Frontiers in immunology · 2024Article
- CATD: a reproducible pipeline for selecting cell-type deconvolution methods across tissues.Bioinformatics advances · 2024Article
- Leprosy: treatment, prevention, immune response and gene function.Frontiers in immunology · 2024Review
- Macrophage Biology in Human Granulomatous Skin Inflammation.International journal of molecular sciences · 2023Review
- MuSiC2: cell-type deconvolution for multi-condition bulk RNA-seq data.Briefings in bioinformatics · 2022Article
- The cellular architecture of the antimicrobial response network in human leprosy granulomas.Nature immunology · 2021Article
- Blood RNA signature RISK4LEP predicts leprosy years before clinical onset.EBioMedicine · 2021Article
- Neutrophil NETworking in ENL: Potential as a Putative Biomarker: Future Insights.Frontiers in medicine · 2021Review
- Analysis of Bulk RNA Sequencing Data Reveals Novel Transcription Factors Associated With Immune Infiltration Among Multiple Cancers.Frontiers in immunology · 2021Article
- Large-Scale Gene Expression Signatures Reveal a Microbicidal Pattern of Activation inFrontiers in immunology · 2021Article
- Host-Related Laboratory Parameters for Leprosy Reactions.Frontiers in medicine · 2021Review
- Advances in the Immunology and Genetics of Leprosy.Frontiers in immunology · 2020Review
- microRNAs in Mycobacterial Infection: Modulation of Host Immune Response and Apoptotic Pathways.Immune network · 2019Review
- Identification of a systemic interferon-γ inducible antimicrobial gene signature in leprosy patients undergoing reversal reaction.PLoS neglected tropical diseases · 2019Article
- Organization of the Skin Immune System and Compartmentalized Immune Responses in Infectious Diseases.Clinical microbiology reviews · 2019Review
- High-Throughput Identification of the Plasma Proteomic Signature of Inflammatory Bowel Disease.Journal of Crohn's & colitis · 2019Article
- Neutrophils in Leprosy.Frontiers in immunology · 2019Review
- KLRD1-expressing natural killer cells predict influenza susceptibility.Genome medicine · 2018Article
Corrections and comments
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Authors and funding
18 authors at 7 institutions in 4 countries.
Funding
Abstract
Transcriptome profiles derived from the site of human disease have led to the identification of genes that contribute to pathogenesis, yet the complex mixture of cell types in these lesions has been an obstacle for defining specific mechanisms. Leprosy provides an outstanding model to study host defense and pathogenesis in a human infectious disease, given its clinical spectrum, which interrelates with the host immunologic and pathologic responses. Here, we investigated gene expression profiles derived from skin lesions for each clinical subtype of leprosy, analyzing gene coexpression modules by cell-type deconvolution. In lesions from tuberculoid leprosy patients, those with the self-limited form of the disease, dendritic cells were linked with
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.