Evidence map›Paper›PMID 27699247›Full record

ArticleJCI insight2016

PKA regulatory subunit 1A inactivating mutation induces serotonin signaling in primary pigmented nodular adrenal disease.

Zakariae Bram, Estelle Louiset, Bruno Ragazzon, Sylvie Renouf, Julien Wils, Céline Duparc, Isabelle Boutelet, Marthe Rizk-Rabin, Rossella Libé, Jacques Young and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JCI insight, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 30 citations in OpenAlex.

  1. Cushing syndrome.Nature reviews. Disease primers · 2025
    Review
  2. Review
  3. Adrenal Cushing's syndrome in children.Frontiers in endocrinology · 2023
    Review
  4. Treatment of Primary Pigmented Nodular Adrenocortical Disease.Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme · 2022
    Review
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 1 institution in 1 country.

Zakariae BramNormandie University, UNIROUEN, INSERM, U982, Laboratoire Differenciation et Communication Neuronale et Neuroendocrine, 76000 Rouen, France.
Estelle LouisetNormandie University, UNIROUEN, INSERM, U982, Laboratoire Differenciation et Communication Neuronale et Neuroendocrine, 76000 Rouen, France.
Bruno RagazzonINSERM, U1016, University Paris V, Cochin Institute, Paris, France.
Sylvie RenoufNormandie University, UNIROUEN, INSERM, U982, Laboratoire Differenciation et Communication Neuronale et Neuroendocrine, 76000 Rouen, France.
Julien WilsNormandie University, UNIROUEN, INSERM, U982, Laboratoire Differenciation et Communication Neuronale et Neuroendocrine, 76000 Rouen, France.
Céline DuparcNormandie University, UNIROUEN, INSERM, U982, Laboratoire Differenciation et Communication Neuronale et Neuroendocrine, 76000 Rouen, France.
Isabelle BouteletNormandie University, UNIROUEN, INSERM, U982, Laboratoire Differenciation et Communication Neuronale et Neuroendocrine, 76000 Rouen, France.
Marthe Rizk-RabinINSERM, U1016, University Paris V, Cochin Institute, Paris, France.
Rossella LibéINSERM, U1016, University Paris V, Cochin Institute, Paris, France.
Jacques YoungUniversity Paris Sud, INSERM Unité 693, Le Kremlin-Bicêtre, France.
Dennis CarsonDepartment of Paediatric Endocrinology, Royal Belfast Hospital for Sick Children, Belfast, United Kingdom.
Marie-Christine VantyghemCHU Lille, Endocrinology Diabetology and Metabolism, Lille, France.
Eva SzarekSection of Endocrinology and Genetics, PDEGEN, NICHD, Bethesda, Maryland, USA.
Antoine MartinezCNRS UMR6247, INSERM U931, Gred, Clermont Université, Aubière, France.
Constantine A StratakisSection of Endocrinology and Genetics, PDEGEN, NICHD, Bethesda, Maryland, USA.
Jérôme BertheratINSERM, U1016, University Paris V, Cochin Institute, Paris, France.
Hervé LefebvreNormandie University, UNIROUEN, INSERM, U982, Laboratoire Differenciation et Communication Neuronale et Neuroendocrine, 76000 Rouen, France.
Royal Belfast Hospital for Sick Children · GB

Funding

Molecular Genetics of Endocrine Tumors and Related DisordersZIAHD008920 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI STRATAKIS, CONSTANTINE A. · 2012 to 2021
$25.8M
6 · The paper itself

Abstract

Primary pigmented nodular adrenocortical disease (PPNAD) is a rare cause of ACTH-independent hypercortisolism. The disease is primarily caused by germline mutations of the protein kinase A (PKA) regulatory subunit 1A (

Indexed as

AdolescentAdrenal Cortex DiseasesAdultCell LineChildChild, PreschoolCyclic AMP-Dependent Protein Kinase RIalpha SubunitFemaleHumansMaleMiddle AgedMutationReceptors, SerotoninSerotoninSignal TransductionTryptophan HydroxylaseCyclic AMP-Dependent Protein Kinase RIalpha SubunitPRKAR1A protein, humanReceptors, SerotoninSerotoninTPH2 protein, humanTryptophan Hydroxylase

Identifiers

PMID27699247
PMCPMC5033753
OpenAlexW2521132816

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.