ArticleJCI insight2016
Tissue-specific metabolic reprogramming drives nutrient flux in diabetic complications.
Open access · goldAbstract read
In one paragraph
Article in JCI insight, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 187 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
187citing papers in PubMed, 2 pooled it
10.5field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
187 citing papers in PubMed, 2 syntheses or guidelines pooled it, 257 citations in OpenAlex.
- Role and mechanisms of SGLT-2 inhibitors in the treatment of diabetic kidney disease.Frontiers in immunology · 2023Pooled it
- Mitochondrial Dysfunction in Individuals with Diabetic Kidney Disease: A Systematic Review.Cells · 2022Pooled it
- Metabolic surgery mitigates early kidney injury in obese youth with diabetes by suppressing mTORC1/JAK/STAT signaling.The Journal of clinical investigation · 2026Trial
- Plasma levels of carboxylic acids are markers of early kidney dysfunction in young people with type 1 diabetes.Pediatric nephrology (Berlin, Germany) · 2023Trial
- Urine tricarboxylic acid cycle signatures of early-stage diabetic kidney disease.Metabolomics : Official journal of the Metabolomic Society · 2021Trial
- Renal gluconeogenesis: a key metabolic hub in health and kidney disease.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2026Review
- Apical proximal tubule fatty acid uptake-generated ceramides cause endoplasmic reticulum stress from altered membrane fluidity.JCI insight · 2026Article
- Natural products modulate renal metabolic reprogramming in diabetic kidney disease.Journal of translational internal medicine · 2026Article
- FBP1 Is Associated with Attenuated Mitochondrial Injury in Renal Tubular Epithelial Cells of Diabetic Kidney Disease via Modulation of Lactate Metabolism.International journal of molecular sciences · 2026Article
- Mitochondrial metabolic reprogramming drives diabetic kidney disease progression: cell-specific mechanisms, metabolic memory, and targeted strategies.Molecular medicine (Cambridge, Mass.) · 2026Review
- Kidney-Vascular Metabolic Crosstalk: Altered Lipoproteins in CKD.Circulation research · 2026Review
- Hypoxia inducible factor network reflects kidney disease progression in diabetes and sodium-glucose co-transporters inhibition.Signal transduction and targeted therapy · 2026Article
- Metabolomics for Preclinical Detection of Diabetic Kidney Disease: A Comprehensive Review.International journal of molecular sciences · 2026Review
- Analysis of high glucose injury using human induced pluripotent stem cell-derived kidney organoids.BMC nephrology · 2026Article
- Metabolic reprogramming in diabetic complications: mechanisms, pathologies, and molecular evidence from multi-organ studies.Frontiers in immunology · 2026Review
- Article
- Dietary monounsaturated fatty acids reduce nerve inflammation and improve nerve function in murine models of obesity.Frontiers in immunology · 2026Article
- New Insights into the Role of Mitochondrial Dysfunction in Diabetic Kidney Disease in the Omics Era.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Review
- Canagliflozin Promotes Structural and Functional Changes in Proximal Tubular Cell Mitochondria of Hypertensive-Diabetic Mice.International journal of molecular sciences · 2025Article
- Limitations in PPARα-dependent mitochondrial programming restrain the differentiation of human stem cell-derived β cells.Nature communications · 2025Article
127 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
26 authors at 6 institutions in 3 countries.
Kelli M SasDepartment of Internal Medicine.
Pradeep KayampillyDepartment of Internal Medicine.
Jaeman ByunDepartment of Internal Medicine.
Viji NairDepartment of Internal Medicine.
Lucy M HinderDepartment of Neurology, University of Michigan, Ann Arbor, Michigan, USA.
Junguk HurDepartment of Biomedical Sciences, University of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota, USA.
Hongyu ZhangDepartment of Internal Medicine.
Chengmao LinDepartment of Ophthalmology and Visual Sciences.
Nathan R QiDepartment of Internal Medicine.
George MichailidisDepartment of Statistics, University of Michigan, Ann Arbor, Michigan, USA.
Per-Henrik GroopFolkhälsan Institute of Genetics, Folkhälsan Research Center, Biomedicum Helsinki, Helsinki, Finland.
Robert G NelsonDiabetes Epidemiology and Clinical Research Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA.
Manjula DarshiInstitute of Metabolomic Medicine and Center for Renal Translational Medicine, Department of Medicine, University of California San Diego, and Veterans Administration San Diego Healthcare System, La Jolla, California, USA.
Kumar SharmaInstitute of Metabolomic Medicine and Center for Renal Translational Medicine, Department of Medicine, University of California San Diego, and Veterans Administration San Diego Healthcare System, La Jolla, California, USA.
Jeffrey R SchellingDepartment of Medicine.
John R SedorDepartment of Medicine.
Rodica Pop-BusuiDepartment of Internal Medicine.
Joel M WeinbergDepartment of Internal Medicine.
Scott A SoleimanpourDepartment of Internal Medicine.
Steven F AbcouwerDepartment of Ophthalmology and Visual Sciences.
Thomas W GardnerDepartment of Ophthalmology and Visual Sciences.
Charles F BurantDepartment of Internal Medicine.
Eva L FeldmanDepartment of Neurology, University of Michigan, Ann Arbor, Michigan, USA.
Matthias KretzlerDepartment of Internal Medicine.
Frank C BrosiusDepartment of Internal Medicine.
Subramaniam PennathurDepartment of Internal Medicine.
University of Michigan–Ann Arbor · USUniversity of California, San Diego · USCase Western Reserve University · USFolkhälsans Forskningscentrum · FINational Institute of Diabetes and Digestive and Kidney Diseases · USUniversity of North Dakota · US
Funding
Michigan Institute for Clinical and Health Research (MCHR)UL1TR000433 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MASHOUR, GEORGE ALEXANDER · 2012 to 2016
$49.9MRegional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mehboob A Hussain · 2013 to 2026
$24.3MZosuquidar trihydrochloride for acute myeloid leukemia &refractory anemiaM01RR000080 · NCRR · UNIVERSITY HOSPITALS OF CLEVELAND · PI DEARBORN, DORR GELLATLY · 1985 to 2007
$22.2MPilot and Feasibility (P and F) ProgramP30DK089503 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Kanakadurga Singer · 2010 to 2026
$20.3MIntegrated Systems Biology Approach to Diabetic Microvascular ComplicationsR24DK082841 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ABCOUWER, STEVEN F, BROSIUS, FRANK C · 2008 to 2020
$13.1MUniversity of Michigan O'Brien Kidney Translational Core CenterP30DK081943 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BROSIUS, FRANK C · 2008 to 2022
$12.9MEpidemiology, Pathophysiology and Treatment of Diabetic NephropathyZIADK069062 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI NELSON, ROBERT G · 2009 to 2023
$10.1MStatistics and Bioinformatics Core - WangU24DK097153 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BURANT, CHARLES F · 2012 to 2017
$10.1MMichigan Mouse Metabolic Phenotyping CenterU2CDK110768 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ELIAS, CAROL FUZETI · 2016 to 2021
$6.2MNovel Paradigms in Diabetic ComplicationsDP3DK094352 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SHARMA, KUMAR · 2011 to 2011
$6.0MTissue-Specific Metabolic Reprogramming in Diabetic ComplicationsDP3DK094292 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BROSIUS, FRANK C, BURANT, CHARLES F · 2011 to 2011
$5.5MRegulation of Retinal Cell Death in DiabetesR01EY020582 · NEI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ABCOUWER, STEVEN F, GARDNER, THOMAS W. · 2010 to 2018
$4.0MBLRD VA I01 BX002367NCATS NIH HHS UL1 TR000433NCRR NIH HHS M01 RR000080NEI NIH HHS R01 EY020582NHLBI NIH HHS K01 HL124050NIDDK NIH HHS DP3 DK094292NIDDK NIH HHS DP3 DK094352NIDDK NIH HHS K08 DK089117NIDDK NIH HHS P30 DK020572NIDDK NIH HHS P30 DK081943NIDDK NIH HHS P30 DK089503NIDDK NIH HHS R01 DK059997NIDDK NIH HHS R01 DK108921NIDDK NIH HHS R03 DK106304NIDDK NIH HHS R24 DK082841NIDDK NIH HHS R56 DK108921NIDDK NIH HHS U01 DK057329NIDDK NIH HHS U24 DK097153NIDDK NIH HHS U2C DK110768NIGMS NIH HHS R01 GM114029
Abstract
Diabetes is associated with altered cellular metabolism, but how altered metabolism contributes to the development of diabetic complications is unknown. We used the BKS
Indexed as
Carbohydrate MetabolismLipid MetabolismAdultAnimalsBiomarkersCitric Acid CycleDiabetes Mellitus, ExperimentalDiabetes Mellitus, Type 2Diabetic NephropathiesFemaleHumansIndians, North AmericanKidneyMaleMetabolomicsMiceBiomarkers
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.