ArticleJCI insight2016
Autophagy-dependent regulatory T cells are critical for the control of graft-versus-host disease.
Open access · goldAbstract read
In one paragraph
Article in JCI insight, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 57 citations in OpenAlex.
- Identification of alterations of immunometabolism associated with Pompe disease.Cellular and molecular life sciences : CMLS · 2026Article
- Autophagy and mitophagy in dermatological disease: a comprehensive review from molecular pathways to therapeutic frontiers.Biology direct · 2025Review
- Role of autophagy in rejection after solid organ transplantation: A systematic review of the literature.World journal of transplantation · 2025Review
- Loss of ATG5 impairs CD4+ T cell activation and promotes anti-tumor responses.Frontiers in immunology · 2025Article
- Complex Role of Regulatory T Cells (Tregs) in the Tumor Microenvironment: Their Molecular Mechanisms and Bidirectional Effects on Cancer Progression.International journal of molecular sciences · 2024Review
- Article
- Autophagy differentially regulates tissue tolerance of distinct target organs in graft-versus-host disease models.The Journal of clinical investigation · 2024Article
- Proteostasis in T cell aging.Seminars in immunology · 2023Review
- Autoimmunity and Carcinogenesis: Their Relationship under the Umbrella of Autophagy.Biomedicines · 2023Review
- Autophagy and tumorigenesis.The FEBS journal · 2022Review
- Autophagy in Cancer Immunotherapy.Cells · 2022Review
- Autophagy: Guardian of Skin Barrier.Biomedicines · 2022Review
- Review
- The Role of Autophagy in the Function of CD4Frontiers in pharmacology · 2022Review
- Hallmarks of T cell aging.Nature immunology · 2021Review
- Mesenchymal stromal cell mitochondrial transfer to human induced T-regulatory cells mediates FOXP3 stability.Scientific reports · 2021Article
- Autophagy in tumour immunity and therapy.Nature reviews. Cancer · 2021Review
- ATG5-Dependent Autophagy Uncouples T-cell Proliferative and Effector Functions and Separates Graft-versus-Host Disease from Graft-versus-Leukemia.Cancer research · 2021Article
- A Central Role for Atg5 in Microbiota-Dependent Foxp3Frontiers in immunology · 2021Article
- Prognosis and Characterization of Immune Microenvironment in Acute Myeloid Leukemia Through Identification of an Autophagy-Related Signature.Frontiers in immunology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
23 authors at 5 institutions in 1 country.
Laëtitia Le TexierImmunology Department, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Katie E LineburgImmunology Department, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Benjamin CaoManufacturing, Commonwealth Scientific and Industrial Research Organization (CSIRO), Melbourne, Victoria, Australia.
Cameron McDonald-HymanPediatric Blood and Marrow Transplantation Program, University of Minnesota, Minneapolis, Minnesota, USA.
Lucie Leveque-El MouttieImmunology Department, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Jemma NichollsImmunology Department, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Michelle MelinoImmunology Department, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Blessy C NalkurthiImmunology Department, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Kylie A AlexanderImmunology Department, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Bianca TealImmunology Department, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Stephen J BlakeImmunology Department, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Fernando Souza-Fonseca-GuimaraesImmunology Department, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Christian R EngwerdaImmunology Department, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Rachel D KunsImmunology Department, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Steven W LaneImmunology Department, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Michele TengImmunology Department, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Charis TehMolecular Genetics of Cancer Division and Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
Daniel GrayDepartment of Medical Biology, University of Melbourne, Melbourne, Victoria, Australia.
Andrew D CloustonEnvoi Specialist Pathologists, Brisbane, Queensland, Australia.
Susan K NilssonManufacturing, Commonwealth Scientific and Industrial Research Organization (CSIRO), Melbourne, Victoria, Australia.
Bruce R BlazarPediatric Blood and Marrow Transplantation Program, University of Minnesota, Minneapolis, Minnesota, USA.
Geoffrey R HillImmunology Department, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Kelli Pa MacDonaldImmunology Department, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
QIMR Berghofer Medical Research Institute · AUAustralian Regenerative Medicine Institute · AURoyal Brisbane and Women's Hospital · AUEnvoi Specialist Pathologists · AUUniversity of Melbourne · AU
Funding
Trial Design and Biostatistical Support CoreP01CA065493 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Mark J Osborn · 1995 to 2026
$48.2MTransgenic/KnockoutP01AI056299 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI SHARPE, ARLENE H. · 2003 to 2023
$42.5MProject 3: Humoral Targets and B Cell Biology in Chronic Graft-vs.-Host DiseaseP01CA142106 · NCI · DANA-FARBER CANCER INST · PI CUTLER, COREY S · 2009 to 2019
$17.5MEnhancing Treg Therapeutic Efficacy in GVHDR01HL118979 · NHLBI · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R, HIPPEN, KELI L · 2014 to 2025
$6.7MIN VIVO PREVENTION OF MURINE GVHDR01AI034495 · NIAID · UNIVERSITY OF MINNESOTA TWIN CITIES · PI BLAZAR, BRUCE R · 1993 to 2016
$6.2MT-CELL TARGETING FOR GVHDR01HL056067 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI BLAZAR, BRUCE R · 1995 to 2022
$5.4MModifying Regulatory T-cell signaling to enhance prevention of GVHDF30HL121873 · NHLBI · UNIVERSITY OF MINNESOTA · PI MCDONALD-HYMAN, CAMERON S · 2014 to 2017
$137kNCI NIH HHS P01 CA065493NCI NIH HHS P01 CA142106NHLBI NIH HHS F30 HL121873NHLBI NIH HHS R01 HL056067NHLBI NIH HHS R01 HL118979NIAID NIH HHS P01 AI056299NIAID NIH HHS R01 AI034495
Abstract
Regulatory T cells (Tregs) play a crucial role in the maintenance of peripheral tolerance. Quantitative and/or qualitative defects in Tregs result in diseases such as autoimmunity, allergy, malignancy, and graft-versus-host disease (GVHD), a serious complication of allogeneic stem cell transplantation (SCT). We recently reported increased expression of autophagy-related genes (
Indexed as
AutophagyAnimalsBone MarrowFemaleGraft vs Host DiseaseHematopoietic Stem Cell TransplantationImmune ToleranceLymphocyte ActivationMiceMice, Inbred BALB CMice, Inbred C57BLT-Lymphocytes, Regulatory
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.