Evidence map›Paper›PMID 27699241›Full record

ArticleJCI insight2016

Adjuvanted multi-epitope vaccines protect HLA-A*11:01 transgenic mice against

Kamal El Bissati, Aziz A Chentoufi, Paulette A Krishack, Ying Zhou, Stuart Woods, Jitender P Dubey, Lo Vang, Joseph Lykins, Kate E Broderick, Ernest Mui and 16 more

Open access · goldAbstract read
In one paragraph

Article in JCI insight, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 45 citations in OpenAlex.

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  13. Comprehensive Overview ofPathogens (Basel, Switzerland) · 2021
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  14. Advances inVaccines · 2021
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  18. Key Limitations and New Insights Into theFrontiers in cellular and infection microbiology · 2020
    Review
  19. Recruitment of Intratumoral CD103Molecular therapy oncolytics · 2019
    Article
  20. Epitope-based vaccine as a universal vaccination strategy againstJournal of advanced veterinary and animal research · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors at 8 institutions in 3 countries.

Kamal El BissatiDepartment of Opthalmology and Visual Science; and Department of Pediatrics, Infectious Diseases Division (RM), The University of Chicago, Chicago, Illinois, USA.
Aziz A ChentoufiPathology and Clinical Laboratory Medicine, Department of Immunology, King Fahad Medical City, Riyadh, Saudi Arabia.
Paulette A KrishackDepartment of Pathology, The University of Chicago, Chicago, Illinois, USA.
Ying ZhouDepartment of Opthalmology and Visual Science; and Department of Pediatrics, Infectious Diseases Division (RM), The University of Chicago, Chicago, Illinois, USA.
Stuart WoodsStrathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, United Kingdom.
Jitender P DubeyUnited States Department of Agriculture, Agricultural Research Service, Beltsville Agricultural Research Center, Animal Parasitic Diseases Laboratory, Beltsville, Maryland, USA.
Lo VangPaxVax Inc., San Diego, California, USA.
Joseph LykinsDepartment of Opthalmology and Visual Science; and Department of Pediatrics, Infectious Diseases Division (RM), The University of Chicago, Chicago, Illinois, USA.
Kate E BroderickDepartment of Research and Development, Inovio Pharmaceuticals, Blue Bell, Pennsylvania, USA.
Ernest MuiDepartment of Opthalmology and Visual Science; and Department of Pediatrics, Infectious Diseases Division (RM), The University of Chicago, Chicago, Illinois, USA.
Yasuhiro SuzukiDepartment of Microbiology, Immunology and Molecular Genetics, University of Kentucky College of Medicine, Lexington, Kentucky, USA.
Qila SaDepartment of Microbiology, Immunology and Molecular Genetics, University of Kentucky College of Medicine, Lexington, Kentucky, USA.
Stephanie BiDepartment of Opthalmology and Visual Science; and Department of Pediatrics, Infectious Diseases Division (RM), The University of Chicago, Chicago, Illinois, USA.
Nestor CardonaDepartment of Opthalmology and Visual Science; and Department of Pediatrics, Infectious Diseases Division (RM), The University of Chicago, Chicago, Illinois, USA.
Shiv K VermaUnited States Department of Agriculture, Agricultural Research Service, Beltsville Agricultural Research Center, Animal Parasitic Diseases Laboratory, Beltsville, Maryland, USA.
Laura FraczekDepartment of Opthalmology and Visual Science; and Department of Pediatrics, Infectious Diseases Division (RM), The University of Chicago, Chicago, Illinois, USA.
Catherine A ReardonDepartment of Pathology, The University of Chicago, Chicago, Illinois, USA.
John SidneyDivision of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, California.
Jeff AlexanderPaxVax Inc., San Diego, California, USA.
Alessandro SetteDivision of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, California.
Tom VedvickInfectious Disease Research Institute, Seattle, Washington, USA.
Chris FoxInfectious Disease Research Institute, Seattle, Washington, USA.
Jeffrey A GuderianInfectious Disease Research Institute, Seattle, Washington, USA.
Steven ReedInfectious Disease Research Institute, Seattle, Washington, USA.
Craig W RobertsStrathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, United Kingdom.
Rima McLeodDepartment of Opthalmology and Visual Science; and Department of Pediatrics, Infectious Diseases Division (RM), The University of Chicago, Chicago, Illinois, USA.
Infectious Disease Research Institute · USBeltsville Agricultural Research Center · USLa Jolla Institute for Immunology · USUniversity of Chicago · USUniversity of Kentucky · USUniversity of Strathclyde · GBInovio Pharmaceuticals (United States) · USKing Fahd Medical City · SA

Funding

Towards a Vaccine to Prevent ToxoplasmosisU01AI077887 · NIAID · UNIVERSITY OF CHICAGO · PI MCLEOD, RIMA L · 2008 to 2012
$4.2M
NIAID NIH HHS U01 AI077887
6 · The paper itself

Abstract

We created and tested multi-epitope DNA or protein vaccines with TLR4 ligand emulsion adjuvant (gluco glucopyranosyl lipid adjuvant in a stable emulsion [GLA-SE]) for their ability to protect against

Indexed as

AnimalsCD8-Positive T-LymphocytesCross-PrimingEpitopes, T-LymphocyteFemaleHLA-A AntigensImmunologic MemoryMiceMice, Inbred C57BLMice, TransgenicProtozoan VaccinesToxoplasmaToxoplasmosisEpitopes, T-LymphocyteHLA-A AntigensProtozoan Vaccines

Identifiers

PMID27699241
PMCPMC5033759
OpenAlexW2521495960

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.