ArticleJCI insight2016
Open access · goldAbstract read
In one paragraph
Article in JCI insight, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 2 pooled it
2.0field-weighted citation impact, top 14% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 2 syntheses or guidelines pooled it, 63 citations in OpenAlex.
- Genetic and environmental risk factors of asthma: a narrative review.Frontiers in immunology · 2026Pooled it
- Meta-analysis of airway epithelium gene expression in asthma.The European respiratory journal · 2018Pooled it
- Mast cells and endothelial cells mediate interleukin-33 and ST2 responses in distal chronic obstructive pulmonary disease lungs.American journal of respiratory and critical care medicine · 2026Article
- Exploring Biomarkers in Congenital Heart Disease: A Case-Control Study of ST2 in Children with Atrial Septal Defects.International journal of molecular sciences · 2026Article
- Sequencing and health data resource of children of African ancestry.Genetics in medicine : official journal of the American College of Medical Genetics · 2026Article
- Genome-wide Association Study IdentifiesAllergy, asthma & immunology research · 2026Article
- Elucidating molecular mechanisms of allergic sensitization to olive pollen through transcriptomics.Frontiers in immunology · 2026Article
- Integration of biobank-scale genetics and plasma proteomics reveals evidence for causal processes in asthma risk and heterogeneity.Cell genomics · 2025Article
- Biological mechanisms and therapeutic prospects of interleukin-33 in pathogenesis and treatment of allergic disease.Journal of inflammation (London, England) · 2025Review
- Targeting alarmins in asthma: From bench to clinic.The Journal of allergy and clinical immunology · 2025Review
- Simulated burn pit smoke condensates cause sustained impact on human airway epithelial cells.Toxicological sciences : an official journal of the Society of Toxicology · 2025Article
- Article
- Interleukin-33-activated basophils promote asthma by regulating Th2 cell entry into lung tissue.The Journal of experimental medicine · 2024Article
- Epithelial Interleukin-1 Receptor-Like-1 Activation Is Contingent on Interleukin-33 Isoforms and Asthma-Related Receptor Variation.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2024Article
- Exploring potential therapeutic targets for asthma: a proteome-wide Mendelian randomization analysis.Journal of translational medicine · 2024Article
- Phenotype wide association study links bronchopulmonary dysplasia with eosinophilia in children.Scientific reports · 2024Article
- Article
- IL-33 controls IL-22-dependent antibacterial defense by modulating the microbiota.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- IL-33 Expression Is Lower in Current Smokers at both Transcriptomic and Protein Levels.American journal of respiratory and critical care medicine · 2023Article
- Airway transcriptome networks identify susceptibility to frequent asthma exacerbations in children.The Journal of allergy and clinical immunology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 3 institutions in 1 country.
Erin D GordonDepartment of Pulmonary and Critical Care Medicine, University of California, San Francisco, San Francisco, California, USA.
Joe PalandraPfizer Inc., Pharmacodynamics and Metabolism, Andover, Massachusetts, USA.
Agata Wesolowska-AndersenCenter for Genes, Environment, and Health, National Jewish Health, Denver, Colorado, USA.
Lando RingelCenter for Genes, Environment, and Health, National Jewish Health, Denver, Colorado, USA.
Cydney L RiosCenter for Genes, Environment, and Health, National Jewish Health, Denver, Colorado, USA.
Marrah E Lachowicz-ScrogginsCardiovascular Research Institute, University of California, San Francisco, San Francisco, California, USA.
Louis Z SharpCardiovascular Research Institute, University of California, San Francisco, San Francisco, California, USA.
Jamie L EvermanCenter for Genes, Environment, and Health, National Jewish Health, Denver, Colorado, USA.
Hannah J MacLeodCardiovascular Research Institute, University of California, San Francisco, San Francisco, California, USA.
Jae W LeeCardiovascular Research Institute, University of California, San Francisco, San Francisco, California, USA.
Robert J MasonDepartment of Medicine, National Jewish Health, Denver, Colorado, USA.
Michael A MatthayDepartment of Pulmonary and Critical Care Medicine, University of California, San Francisco, San Francisco, California, USA.
Richard T SheldonPfizer Inc., Inflammation and Immunology, Cambridge, Massachusetts, USA.
Michael C PetersDepartment of Pulmonary and Critical Care Medicine, University of California, San Francisco, San Francisco, California, USA.
Karl H NockaPfizer Inc., Inflammation and Immunology, Cambridge, Massachusetts, USA.
John V FahyDepartment of Pulmonary and Critical Care Medicine, University of California, San Francisco, San Francisco, California, USA.
Max A SeiboldCenter for Genes, Environment, and Health, National Jewish Health, Denver, Colorado, USA.
University of California, San Francisco · USUniversity of Colorado Denver · USNational Jewish Health · US
Funding
Understanding Asthma EndotypesU19AI077439 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PRESCOTT G WOODRUFF · 2008 to 2026
$41.1MRole of miRNAs in Th2-Driven inflammation in AsthmaP01HL107202 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LOCKSLEY, RICHARD M · 2012 to 2023
$23.3MGenetic Control of Airway Epithelium Gene Expression in Childhood AsthmaticsR01HL128439 · NHLBI · NATIONAL JEWISH HEALTH · PI SEIBOLD, MAX A · 2015 to 2019
$3.1MMethods for high-resolution analysis of genetic effects on gene expressionR01MH101814 · NIMH · UNIVERSITY OF GENEVA · PI BUSTAMANTE, CARLOS DANIEL, DERMITZAKIS, EMMANOUIL · 2013 to 2016
$2.3MHarnessing GTEx to Create Transcriptome Knowledge and Inform Disease BiologyR01MH101820 · NIMH · UNIVERSITY OF CHICAGO · PI COX, NANCY J, NICOLAE, DAN LIVIU · 2013 to 2015
$2.3MIdentification and validation of cell specific eQTLs by Bayesian modelingR01MH101822 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI BROWN, CHRISTOPHER DAVID, ENGELHARDT, BARBARA · 2013 to 2016
$1.9MUCSF Career Development Program in Omics of Lung DiseasesK12HL119997 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BURCHARD, ESTEBAN GONZALEZ, ERLE, DAVID J · 2013 to 2017
$1.4MGenetic Regulation of Gene Expression and its Impact on Phenotypes - SupplementR01MH101782 · NIMH · STANFORD UNIVERSITY · PI SABATTI, CHIARA · 2013 to 2016
$1.3MMODELING THE EFFECTS OF STRUCTURAL VARIATION IN GTEX DATA AND MENDELIAN DISEASER01MH101810 · NIMH · WASHINGTON UNIVERSITY · PI CONRAD, DONALD F. · 2013 to 2016
$1.3MSystems approaches to link tissue-specific expression to diseaseR01MH101819 · NIMH · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI NOBEL, ANDREW B, WRIGHT, FRED A. · 2013 to 2015
$1.3MStatistical analysis of gene expression quantitative trait loci (eQTL)R01MH101825 · NIMH · UNIVERSITY OF CHICAGO · PI STEPHENS, MATTHEW · 2013 to 2015
$1.1MStatistical analysis of gene expression quantitative trait loci (eQTL)R01MH090951 · NIMH · UNIVERSITY OF CHICAGO · PI PRITCHARD, JONATHAN K · 2010 to 2012
$873kCCR NIH HHS HHSN261200800001CNCI NIH HHS HHSN261200800001ENHLBI NIH HHS HHSN268201000029CNHLBI NIH HHS K08 HL114645NHLBI NIH HHS K12 HL119997NHLBI NIH HHS P01 HL107202NHLBI NIH HHS R01 HL128439NIAID NIH HHS U19 AI077439NIMH NIH HHS R01 MH090936NIMH NIH HHS R01 MH090937NIMH NIH HHS R01 MH090941NIMH NIH HHS R01 MH090948NIMH NIH HHS R01 MH090951NIMH NIH HHS R01 MH101782NIMH NIH HHS R01 MH101810NIMH NIH HHS R01 MH101814NIMH NIH HHS R01 MH101819NIMH NIH HHS R01 MH101820NIMH NIH HHS R01 MH101822NIMH NIH HHS R01 MH101825
Abstract
Genome-wide association studies of asthma have identified genetic variants in the
Indexed as
Quantitative Trait LociAsthmaCells, CulturedGenetic Predisposition to DiseaseHumansInflammationInterleukin-1 Receptor-Like 1 ProteinInterleukin-33Polymorphism, Single NucleotideIL1RL1 protein, humanInterleukin-1 Receptor-Like 1 ProteinInterleukin-33
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.