ArticleJCI insight2016
Gene pathway development in human epicardial adipose tissue during early life.
Article in JCI insight, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- The Implications of Aging on Vascular Health.International journal of molecular sciences · 2024Review
- Fully automated epicardial adipose tissue volume quantification with deep learning and relationship with CAC score and micro/macrovascular complications in people living with type 2 diabetes: the multicenter EPIDIAB study.Cardiovascular diabetology · 2024Article
- Central Obesity is Associated with Increased Left Ventricular Maximal Wall Thickness and Intrathoracic Adipose Tissue Measured with Cardiac Magnetic Resonance.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2024Article
- Single-cell transcriptomics reveals zinc and copper ions homeostasis in epicardial adipose tissue of heart failure.International journal of biological sciences · 2023Article
- Aging Effects on Epicardial Adipose Tissue.Frontiers in aging · 2021Review
- Adipose tissue in health and disease through the lens of its building blocks.Scientific reports · 2020Article
- Comprehensive analysis of differential immunocyte infiltration and the potential ceRNA networks during epicardial adipose tissue development in congenital heart disease.Journal of translational medicine · 2020Article
- Transcriptional analysis of adipose tissue during development reveals depot-specific responsiveness to maternal dietary supplementation.Scientific reports · 2018Article
- Functional characterization of the Ucp1-associated oxidative phenotype of human epicardial adipose tissue.Scientific reports · 2017Article
- Epicardial adipose tissue as a metabolic transducer: role in heart failure and coronary artery disease.Heart failure reviews · 2017 · on this mapReview
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Studies in rodents and newborn humans demonstrate the influence of brown adipose tissue (BAT) in temperature control and energy balance and a critical role in the regulation of body weight. Here, we obtained samples of epicardial adipose tissue (EAT) from neonates, infants, and children in order to evaluate changes in their transcriptional landscape by applying a systems biology approach. Surprisingly, these analyses revealed that the transition to infancy is a critical stage for changes in the morphology of EAT and is reflected in unique gene expression patterns of a substantial proportion of thermogenic gene transcripts (~10%). Our results also indicated that the pattern of gene expression represents a distinct developmental stage, even after the rebound in abundance of thermogenic genes in later childhood. Using weighted gene coexpression network analyses, we found precise anthropometric-specific correlations with changes in gene expression and the decline of thermogenic capacity within EAT. In addition, these results indicate a sequential order of transcriptional events affecting cellular pathways, which could potentially explain the variation in the amount, or activity, of BAT in adulthood. Together, these results provide a resource to elucidate gene regulatory mechanisms underlying the progressive development of BAT during early life.
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