Evidence map›Paper›PMID 27699182›Full record

ArticleJournal of immunology research2016

Study of Soluble HLA-G in Congenital Human Cytomegalovirus Infection.

Roberta Rizzo, Liliana Gabrielli, Daria Bortolotti, Valentina Gentili, Giulia Piccirilli, Angela Chiereghin, Claudia Pavia, Silvia Bolzani, Brunella Guerra, Giuliana Simonazzi and 6 more

Open access · goldAbstract read
In one paragraph

Article in Journal of immunology research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Induction of pulmonary HLA-G expression by SARS-CoV-2 infection.Cellular and molecular life sciences : CMLS · 2022
    Article
  3. Article
  4. Article
  5. Role of HLA-G in Viral Infections.Frontiers in immunology · 2022
    Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 1 country.

Roberta RizzoDepartment of Medical Sciences, Section of Microbiology and Medical Genetics, University of Ferrara, Ferrara, Italy.ORCID 0000-0001-9507-9126
Liliana GabrielliOperative Unit of Clinical Microbiology, St. Orsola-Malpighi University Hospital, Bologna, Italy.
Daria BortolottiDepartment of Medical Sciences, Section of Microbiology and Medical Genetics, University of Ferrara, Ferrara, Italy.
Valentina GentiliDepartment of Medical Sciences, Section of Microbiology and Medical Genetics, University of Ferrara, Ferrara, Italy.
Giulia PiccirilliOperative Unit of Clinical Microbiology, St. Orsola-Malpighi University Hospital, Bologna, Italy.
Angela ChiereghinOperative Unit of Clinical Microbiology, St. Orsola-Malpighi University Hospital, Bologna, Italy.
Claudia PaviaOperative Unit of Clinical Microbiology, St. Orsola-Malpighi University Hospital, Bologna, Italy.
Silvia BolzaniDepartment of Medical Sciences, Section of Microbiology and Medical Genetics, University of Ferrara, Ferrara, Italy.
Brunella GuerraOperative Unit of Obstetrics and Prenatal Medicine, Department of Medical and Surgical Sciences, St. Orsola-Malpighi University Hospital, University of Bologna, Bologna, Italy.
Giuliana SimonazziOperative Unit of Obstetrics and Prenatal Medicine, Department of Medical and Surgical Sciences, St. Orsola-Malpighi University Hospital, University of Bologna, Bologna, Italy.
Francesca CerviOperative Unit of Obstetrics and Prenatal Medicine, Department of Medical and Surgical Sciences, St. Orsola-Malpighi University Hospital, University of Bologna, Bologna, Italy.
Maria Grazia CaprettiOperative Unit of Neonatology, St. Orsola-Malpighi University Hospital, Bologna, Italy.
Enrico FainardiOperative Unit of Neuroradiology, Careggi University Hospital, Firenze, Italy.ORCID 0000-0003-0477-724X
Dario Di LucaDepartment of Medical Sciences, Section of Microbiology and Medical Genetics, University of Ferrara, Ferrara, Italy.
Maria Paola LandiniOperative Unit of Clinical Microbiology, Department of Specialised, Experimental, and Diagnostic Medicine, St. Orsola-Malpighi University Hospital, University of Bologna, Bologna, Italy.
Tiziana LazzarottoOperative Unit of Clinical Microbiology, Department of Specialised, Experimental, and Diagnostic Medicine, St. Orsola-Malpighi University Hospital, University of Bologna, Bologna, Italy.
IRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola · ITUniversity of Ferrara · ITAzienda Ospedaliero-Universitaria Careggi · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human leukocyte antigen-G (HLA-G) is a nonclassical HLA class I antigen that is expressed during pregnancy contributing to maternal-fetal tolerance. HLA-G can be expressed as membrane-bound and soluble forms. HLA-G expression increases strongly during viral infections such as congenital human cytomegalovirus (HCMV) infections, with functional consequences in immunoregulation. In this work we investigated the expression of soluble (s)HLA-G and beta-2 microglobulin (component of HLA) molecules in correlation with the risk of transmission and severity of congenital HCMV infection. We analyzed 182 blood samples from 130 pregnant women and 52 nonpregnant women and 56 amniotic fluid samples from women experiencing primary HCMV infection. The median levels of sHLA-G in maternal serum of women with primary HCMV infection were higher in comparison with nonprimary and uninfected pregnant women (

Indexed as

AdolescentAdultAmniotic FluidAntibodies, Viralbeta 2-MicroglobulinBiomarkersCytomegalovirusCytomegalovirus InfectionsFemaleFetusGestational AgeHLA-G AntigensHumansPregnancyPregnancy Complications, InfectiousYoung AdultAntibodies, Viralbeta 2-MicroglobulinBiomarkersHLA-G Antigens

Identifiers

PMID27699182
PMCPMC5029053
OpenAlexW2515212077

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.