Evidence map›Paper›PMID 27699138›Full record

ArticleBiomedical optics express2016

Procedures for risk-stratification of lung cancer using buccal nanocytology.

H Subramanian, P Viswanathan, L Cherkezyan, R Iyengar, S Rozhok, M Verleye, J Derbas, J Czarnecki, H K Roy, V Backman

Abstract read
In one paragraph

Article in Biomedical optics express, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Molecular biomarkers in early stage lung cancer.Translational lung cancer research · 2021
    Review
  4. Article
  5. miR-34a inhibits tumorigenesis of NSCLC via targeting SIRT6.International journal of clinical and experimental pathology · 2018
    Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

H SubramanianNorthwestern University, Biomedical Engineering Department, Evanston, Illinois 60208, USA; NanoCytomics LLC, Evanston, Illinois 60201, USA.
P ViswanathanNorthwestern University, Biomedical Engineering Department, Evanston, Illinois 60208, USA.
L CherkezyanNorthwestern University, Biomedical Engineering Department, Evanston, Illinois 60208, USA.
R IyengarNanoCytomics LLC, Evanston, Illinois 60201, USA.
S RozhokNanoCytomics LLC, Evanston, Illinois 60201, USA.
M VerleyeNanoCytomics LLC, Evanston, Illinois 60201, USA.
J DerbasNanoCytomics LLC, Evanston, Illinois 60201, USA.
J CzarneckiNorthwestern University, Biomedical Engineering Department, Evanston, Illinois 60208, USA.
H K RoyBoston University Medical Center, Boston, Massachusetts, 02118, USA.
V BackmanNorthwestern University, Biomedical Engineering Department, Evanston, Illinois 60208, USA.

Funding

Buccal Nanocytological Risk Stratification to Personalize Lung Cancer ScreeningR44CA206844 · NCI · NANOCYTOMICS, LLC · PI SUBRAMANIAN, HARIHARAN · 2016 to 2017
$1.5M
NCI NIH HHS R44 CA206844
6 · The paper itself

Abstract

Lung cancer is the leading cause of cancer deaths in the U.S. with survival dramatically depending on stage at diagnosis. We had earlier reported that nanocytology of buccal cells can accurately risk-stratify smokers for the presence of early and late-stage lung cancer. To translate the technique into clinical practice, standardization of operating procedures is necessary to consistently yield precise and repeatable results. Here, we develop and validate simple, robust, and easily implementable procedures for specimen collection, processing, etc. in addition to a commercially-viable instrument prototype. Results of this work enable translation of the technology from academic lab to physicians' office.

Indexed as

(110.0180) Microscopy(110.2960) Image analysis(120.0120) Instrumentation, measurement, and metrology(170.1610) Clinical applications

Identifiers

PMID27699138
PMCPMC5030050

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.