ArticleBiomedical optics express2016
Imaging brain activity during seizures in freely behaving rats using a miniature multi-modal imaging system.
Article in Biomedical optics express, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Article
- Article
- 3D Printing a Low-Cost Miniature Accommodating Optical Microscope.Advanced materials (Deerfield Beach, Fla.) · 2023Article
- Fiberoptic hemodynamic spectroscopy reveals abnormal cerebrovascular reactivity in a freely moving mouse model of Alzheimer's disease.Frontiers in molecular neuroscience · 2023Article
- Head-mounted optical imaging and optogenetic stimulation system for use in behaving primates.Cell reports methods · 2022Article
- Modular head-mounted cortical imaging device for chronic monitoring of intrinsic signals in mice.Journal of biomedical optics · 2022Article
- Extendable, large-field multi-modal optical imaging system for measuring tissue hemodynamics.Biomedical optics express · 2020Article
- Dissociation of Cerebral Blood Flow and Femoral Artery Blood Pressure Pulsatility After Cardiac Arrest and Resuscitation in a Rodent Model: Implications for Neurological Recovery.Journal of the American Heart Association · 2020Article
- Refinement of a chronic cranial window implant in the rat for longitudinal in vivo two-photon fluorescence microscopy of neurovascular function.Scientific reports · 2019Article
- A miniature multi-contrast microscope for functional imaging in freely behaving animals.Nature communications · 2019Article
- Transcranial Recording of Electrophysiological Neural Activity in the Rodent BrainFrontiers in neuroscience · 2019Article
- Data compression and improved registration for laser speckle contrast imaging of rodent brains.Biomedical optics express · 2018Article
- Wireless optoelectronic photometers for monitoring neuronal dynamics in the deep brain.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Vertical-cavity surface-emitting laser sources for gigahertz-bandwidth, multiwavelength frequency-domain photon migration.Journal of biomedical optics · 2017Article
- Chronic wide-field imaging of brain hemodynamics in behaving animals.Biomedical optics express · 2017Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report on a miniature label-free imaging system for monitoring brain blood flow and blood oxygenation changes in awake, freely behaving rats. The device, weighing 15 grams, enables imaging in a ∼ 2 × 2 mm field of view with 4.4 μm lateral resolution and 1 - 8 Hz temporal sampling rate. The imaging is performed through a chronically-implanted cranial window that remains optically clear between 2 to > 6 weeks after the craniotomy. This imaging method is well suited for longitudinal studies of chronic models of brain diseases and disorders. In this work, it is applied to monitoring neurovascular coupling during drug-induced absence-like seizures 6 weeks following the craniotomy.
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