Evidence map›Paper›PMID 27699119›Full record

ArticleBiomedical optics express2016

Whole-body multispectral photoacoustic imaging of adult zebrafish.

Na Huang, Heng Guo, Weizhi Qi, Zhiwei Zhang, Jian Rong, Zhen Yuan, Wei Ge, Huabei Jiang, Lei Xi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedical optics express, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Na HuangSchool of Physical Electronics, University of Electronic Science and Technology of China, Chengdu, Sichuan, China; These authors contributed equally to this work.
Heng GuoSchool of Physical Electronics, University of Electronic Science and Technology of China, Chengdu, Sichuan, China; These authors contributed equally to this work.
Weizhi QiSchool of Physical Electronics, University of Electronic Science and Technology of China, Chengdu, Sichuan, China; These authors contributed equally to this work.
Zhiwei ZhangFaculty of Health Sciences, University of Macau, Macau, China.
Jian RongSchool of Physical Electronics, University of Electronic Science and Technology of China, Chengdu, Sichuan, China; Center for Information in Biomedicine, University of Electronic Science and Technology of China, Sichuan, China.
Zhen YuanFaculty of Health Sciences, University of Macau, Macau, China.
Wei GeFaculty of Health Sciences, University of Macau, Macau, China.
Huabei JiangSchool of Physical Electronics, University of Electronic Science and Technology of China, Chengdu, Sichuan, China; Center for Information in Biomedicine, University of Electronic Science and Technology of China, Sichuan, China.
Lei XiSchool of Physical Electronics, University of Electronic Science and Technology of China, Chengdu, Sichuan, China; Center for Information in Biomedicine, University of Electronic Science and Technology of China, Sichuan, China.
University of Electronic Science and Technology of China · CNUniversity of Macau · MO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The zebrafish, an ideal vertebrate for studying developmental biology and genetics, is increasingly being used to understand human diseases, due to its high similarity to the human genome and its optical transparency during embryonic stages. Once the zebrafish has fully developed, especially wild-type breeds, conventional optical imaging techniques have difficulty in imaging the internal organs and structures with sufficient resolution and penetration depth. Even with established mutant lines that remain transparent throughout their life cycle, it is still challenging for purely optical imaging modalities to visualize the organs of juvenile and adult zebrafish at a micro-scale spatial resolution. In this work, we developed a non-invasive three-dimensional photoacoustic imaging platform with an optimized illumination pattern and a cylindrical-scanning-based data collection system to image entire zebrafish with micro-scale resolutions of 80 μm and 600 μm in the lateral and axial directions, respectively. In addition, we employed a multispectral strategy that utilized excitation wavelengths from 690 nm to 930 nm to statistically quantify the relative optical absorption spectrum of major organs.

Indexed as

(170.5120) Photoacoustic imaging(170.6960) Tomography

Identifiers

PMID27699119
PMCPMC5030031
OpenAlexW2512349218

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.