Evidence map›Paper›PMID 27699112›Full record

ArticleBiomedical optics express2016

Continuous cerebral hemodynamic measurement during deep hypothermic circulatory arrest.

David R Busch, Craig G Rusin, Wanda Miller-Hance, Kathy Kibler, Wesley B Baker, Jeffrey S Heinle, Charles D Fraser, Arjun G Yodh, Daniel J Licht, Kenneth M Brady

Open access · goldAbstract read
In one paragraph

Article in Biomedical optics express, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 36 citations in OpenAlex.

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  5. Cerebral blood flow velocity and oxygenation in neonatal aortic arch repair at two perfusion temperatures.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2023
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  17. Non-invasive optical neuromonitoring of the temperature-dependence of cerebral oxygen metabolism during deep hypothermic cardiopulmonary bypass in neonatal swine.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020
    Article
  18. Continuous non-invasive optical monitoring of cerebral blood flow and oxidative metabolism after acute brain injury.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2019
    Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

David R BuschDivision of Neurology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA; Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA 19104, USA.
Craig G RusinDepartments of Pediatrics and Cardiology, Baylor College of Medicine, Houston, TX, 77030 USA.
Wanda Miller-HanceDepartment of Pediatric Cardiovascular Anesthesiology, Baylor College of Medicine, Houston, TX, 77030 USA.
Kathy KiblerDepartment of Pediatrics, Texas Children's Hospital, Houston, TX, 77030, USA.
Wesley B BakerDepartment of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Anesthesiology and Critical Care, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA.
Jeffrey S HeinleDepartment of Surgery, Texas Children's Hospital, Houston, TX, 77030, USA.
Charles D FraserDepartment of Surgery, Texas Children's Hospital, Houston, TX, 77030, USA.
Arjun G YodhDepartment of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA 19104, USA.
Daniel J LichtDivision of Neurology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.
Kenneth M BradyDepartment of Anesthesiology, Baylor College of Medicine, Houston, TX, 77030, USA.
Baylor College of Medicine · USTexas Children's Hospital · USUniversity of Pennsylvania · USChildren's Hospital of Philadelphia · USHospital of the University of Pennsylvania · US

Funding

Training in Molecular Therapeutics for Pediatric CardiologyT32HL007915 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI Robert J Levy, JOSEPH W ROSSANO · 1999 to 2026
$13.4M
Training and DisseminationP41EB015893 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI REDDY, RAVINDER · 2012 to 2019
$11.3M
Diffuse Optics for Acute Stroke ManagementR01NS060653 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI YODH, ARJUN G. · 2008 to 2018
$5.5M
Augmented Physiologic Monitoring to Predict Brain Injury in Infants with CHDR01NS072338 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI LICHT, DANIEL JACQUES · 2011 to 2015
$1.7M
NHLBI NIH HHS T32 HL007915NIBIB NIH HHS P41 EB015893NINDS NIH HHS R01 NS060653NINDS NIH HHS R01 NS072338
6 · The paper itself

Abstract

While survival of children with complex congenital heart defects has improved in recent years, roughly half suffer neurological deficits suspected to be related to cerebral ischemia. Here we report the first demonstration of optical diffuse correlation spectroscopy (DCS) for continuous and non-invasive monitoring of cerebral microvascular blood flow during complex human neonatal or cardiac surgery. Comparison between DCS and Doppler ultrasound flow measurements during deep hypothermia, circulatory arrest, and rewarming were in good agreement. Looking forward, DCS instrumentation, alone and with NIRS, could provide access to flow and metabolic biomarkers needed by clinicians to adjust neuroprotective therapy during surgery.

Indexed as

(170.3890) Medical optics instrumentation(170.6935) Tissue characterization

Identifiers

PMID27699112
PMCPMC5030024
OpenAlexW2514221660

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.